Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Confocal Fluorescence Microscopy01:16

Confocal Fluorescence Microscopy

21.4K
Confocal microscopy is an advanced microscopic technique. The prime advantage of the confocal microscope over other microscopy techniques is its ability to block the out-of-focus light from the illuminated samples using pinholes. It is widely used with fluorescence optics to obtain high-resolution, sharp contrast images. Unlike optical microscopes, confocal microscopes use a focused beam of light laser to scan the entire sample surface at different z-planes. These microscopes are, therefore,...
21.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Flexible and Generic Framework for Complex Nuclear Medicine Scanners Using FreeCAD/GDML Workbench.

Computer-aided design and applications·2026
Same author

Beyond language: generative artificial intelligence as a general computing model for medicine.

The Lancet. Digital health·2026
Same author

Instrumentation Digital Twins in PET and SPECT Imaging: Current Status, Challenges, and Future Directions.

Computational and structural biotechnology journal·2026
Same author

Reassurance-Focused First-Trimester Euploidy Screening With Machine Learning.

Prenatal diagnosis·2026
Same author

Machine learning-assisted event classification in cadmium zinc telluride positron emission tomography detectors leveraging entanglement-informed angular correlations.

Scientific reports·2025
Same author

Toward Integrated Clinical-Computational Nuclear Medicine.

PET clinics·2025

Related Experiment Video

Updated: Feb 24, 2026

Whole-cell Super-Resolution Imaging via DNA-PAINT on a Spinning Disk Confocal with Optical Photon Reassignment
07:12

Whole-cell Super-Resolution Imaging via DNA-PAINT on a Spinning Disk Confocal with Optical Photon Reassignment

Published on: January 6, 2026

313

Maximum-Likelihood--Based Position Decoding of Laser Processed Converging Pixel CsI: Tl Detectors for High-Resolution

Xi Zhang, Arkadiusz Sitek, Lisa Blackberg

    Arxiv
    |February 23, 2026
    PubMed
    Summary

    This study presents a new method for creating high-resolution cesium iodide (CsI: Tl) detectors for single photon emission computed tomography (SPECT). The novel converging-pixel design and advanced algorithms improve SPECT imaging performance.

    More Related Videos

    Direct Imaging of Laser-driven Ultrafast Molecular Rotation
    10:52

    Direct Imaging of Laser-driven Ultrafast Molecular Rotation

    Published on: February 4, 2017

    10.3K
    Infrared Degenerate Four-wave Mixing with Upconversion Detection for Quantitative Gas Sensing
    10:42

    Infrared Degenerate Four-wave Mixing with Upconversion Detection for Quantitative Gas Sensing

    Published on: March 22, 2019

    6.6K

    Related Experiment Videos

    Last Updated: Feb 24, 2026

    Whole-cell Super-Resolution Imaging via DNA-PAINT on a Spinning Disk Confocal with Optical Photon Reassignment
    07:12

    Whole-cell Super-Resolution Imaging via DNA-PAINT on a Spinning Disk Confocal with Optical Photon Reassignment

    Published on: January 6, 2026

    313
    Direct Imaging of Laser-driven Ultrafast Molecular Rotation
    10:52

    Direct Imaging of Laser-driven Ultrafast Molecular Rotation

    Published on: February 4, 2017

    10.3K
    Infrared Degenerate Four-wave Mixing with Upconversion Detection for Quantitative Gas Sensing
    10:42

    Infrared Degenerate Four-wave Mixing with Upconversion Detection for Quantitative Gas Sensing

    Published on: March 22, 2019

    6.6K

    Area of Science:

    • Medical Physics
    • Nuclear Medicine
    • Materials Science

    Background:

    • High spatial resolution is crucial for Single Photon Emission Computed Tomography (SPECT) imaging.
    • Previous Laser Induced Optical Barrier (LIOB) methods achieved high resolution and yield in CsI: Tl detectors.
    • Extending LIOB to a converging-pixel architecture offers potential for improved SPECT detector performance.

    Purpose of the Study:

    • To demonstrate the feasibility of a novel converging-pixel CsI: Tl detector fabrication technique for SPECT.
    • To evaluate the performance of this new architecture using advanced decoding algorithms.
    • To assess the potential for developing next-generation high-performance SPECT detectors.

    Main Methods:

    • Fabrication of a CsI: Tl crystal array with a converging-pixel architecture (1.6x1.6 mm2 entrance, 2x2 mm2 photodetector side).
    • Implementation of Center of Gravity (CoG) and Maximum Likelihood (ML) based decoding algorithms for interaction localization.
    • Utilizing a custom four-axis motion platform for precise beam delivery and data acquisition.

    Main Results:

    • Achieved an energy resolution of 11.79+/-0.53% in collimated experiments.
    • Demonstrated a position localization accuracy of 1.00+/-0.42 mm using nearest neighbor interpolation.
    • Validated the performance of the converging-pixel design with statistical decoding algorithms.

    Conclusions:

    • The novel converging-pixel CsI: Tl detector architecture is feasible for SPECT applications.
    • Combining this architecture with statistical decoding algorithms significantly enhances SPECT detector performance.
    • This approach represents a promising pathway for developing advanced, high-performance SPECT systems.