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Translation and Validation of Myeloproliferative Neoplasm-Symptom Assessment Form (MPN-SAF)-Total Symptom Score
Flordeluna Z Mesina1, Joy Ann V de Castro2, Marissa M Alejandria3
1Section of Clinical Hematology, Department of Medicine, University of Santo Tomas, Manila, Philippines.
Background And Objective:
Myeloproliferative disorders are characterized by symptoms that can potentially impair the quality of life of our Filipino patients. The Myeloproliferative Neoplasm Symptom Assessment Form-Total Symptom Score (MPN-SAF TSS) is used to determine symptoms at baseline and during treatment. A validated Filipino version of this questionnaire would be a helpful tool in assessing the burden of symptoms of Filipino patients with MPN. Understanding the symptom burden and symptom experience of patients with MPN is needed in developing a comprehensive wholistic management plan that addresses the physical and emotional aspects of a chronic disease such as MPN. This study aimed to translate the MPN-SAF TSS to the Filipino language.
Methods:
Translation, validation, and reliability testing of the MPN-SAF TSS was done following the International Society for Pharmacoeconomics and Outcomes Research (ISPOR) guidelines for linguistic translation and validation.
Results:
No major discrepancies were found on forward and backward translation of the MPN-SAF TSS tool. The 0-10 scoring scale (where 0 = absent/as good as it can be and 10 = worst imaginable/daily/as bad as it can be) was deemed appropriate and was retained. Content and face validity as evaluated by Filipino hematologists showed that majority of the translated questions were relevant. Some words were further improved according to their valid recommendations. Ten MPN patients voluntarily answered the updated Filipino version of the questionnaire for face validity and cognitive debriefing was done to further refine the translation according to the patient's perspective. The back translation was identical to the original versions of MPN-SAF TSS.Validity and reliability testing of the revised and translated MPN-SAF TSS among 30 patients with MPN demonstrated that the MPN-SAF TSS Filipino version was conceptually equivalent with the English version, with good internal consistency (Cronbach's alpha=0.89); excellent reliability with an intraclass correlation coefficient of 0.98 and convergent validity of r=0.77.
Conclusion:
The Filipino version of the MPN-SAF TSS was demonstrated to be a valid and reliable tool in evaluating the symptom burden of Filipino patients with MPN.
Insights
A new Filipino version of the Myeloproliferative Neoplasm Symptom Assessment Form-Total Symptom Score (MPN-SAF TSS) is now available. This validated tool accurately measures symptom burden in Filipino patients with myeloproliferative neoplasms.
Area of Science:
- Hematology
- Patient-Reported Outcomes
- Clinical Linguistics
Background:
- Myeloproliferative neoplasms (MPNs) significantly impact Filipino patients' quality of life.
- Assessing symptom burden is crucial for effective MPN management.
- A validated Filipino tool is needed to evaluate MPN symptoms in this population.
Purpose of the Study:
- To translate and validate the Myeloproliferative Neoplasm Symptom Assessment Form-Total Symptom Score (MPN-SAF TSS) into Filipino.
- To ensure the Filipino version is a reliable and accurate measure of symptom burden for Filipino MPN patients.
Main Methods:
- Linguistic translation and validation following International Society for Pharmacoeconomics and Outcomes Research (ISPOR) guidelines.
- Forward and backward translation, content and face validity assessments by hematologists.
- Cognitive debriefing with MPN patients and reliability testing (Cronbach's alpha, ICC).
Main Results:
- The Filipino MPN-SAF TSS demonstrated conceptual equivalence with the English version.
- High internal consistency (Cronbach's alpha=0.89) and excellent reliability (ICC=0.98).
- Good convergent validity (r=0.77) was established.
Conclusions:
- The Filipino version of the MPN-SAF TSS is a valid and reliable instrument.
- This tool will aid in assessing the symptom burden of Filipino MPN patients.
- Facilitates comprehensive management addressing physical and emotional aspects of MPN.
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