The double-positive cells in the tumor microenvironment.
Xinmiao Long1,2,3, Yinfei Du1,2,3, Yinan Li1,2,3
1The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University/Hunan Cancer Hospital, Central South University, Changsha, Hunan Province, China.
Journal of Translational Internal Medicine
|February 23, 2026
Summary
Double-positive cells (DPCs) are crucial in the tumor microenvironment, impacting cancer progression and treatment resistance. Targeting these cells offers potential new cancer therapies.
Area of Science:
- Oncology
- Cell Biology
- Cancer Immunology
Background:
- The tumor microenvironment (TME) is a complex ecosystem influencing cancer progression.
- Interactions within the TME involve immune cells, fibroblasts, endothelial cells, and mesenchymal cells.
- Double-positive cells (DPCs) have emerged as a critical component within the TME.
Purpose of the Study:
- To review the formation, characterization, classification, functions, and clinical significance of DPCs.
- To highlight the role of DPCs in cancer progression and therapeutic resistance.
- To explore the potential of targeting DPCs for novel cancer treatments.
Main Methods:
- Literature review of recent studies on DPCs.
- Analysis of DPC characteristics and functions within the TME.
- Evaluation of the clinical implications of DPCs in cancer.
Main Results:
- DPCs are defined by the co-expression of markers from distinct cell lineages.
- DPCs contribute to enhanced tumor invasiveness and immune evasion.
- DPCs play a role in promoting drug resistance in cancer.
Conclusions:
- DPCs are significant players in the tumor microenvironment, influencing multiple aspects of cancer.
- Targeting DPCs presents a promising strategy for developing new cancer therapeutics.
- Further research into DPCs could revolutionize cancer treatment approaches.
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