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Aggressive Right-Sided Colon Cancer in a Young Adult: Triple-Whammy Mutations (POLE, KRAS, BRCA1/2) Highlight

Ravi Patel1, Ganesh Kumar2, Yash Shah3

  • 1Department of Internal Medicine, Trinity Health Oakland/Wayne State University, Pontiac, MI.

ACG Case Reports Journal
|February 23, 2026
PubMed
Abstract

Keywords:
BRCA 2 mutationBRCA1 mutationKRAS mutationPARP inhibitorPOLE mutationcolorectal cancerearly-onset CRChigh tumor mutational burdenimmune checkpoint inhibitormicrosatellite stablenext-generation sequencingright-sided colon adenocarcinoma

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