Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Aging01:26

Aging

889
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
889
Replicative Cell Senescence02:15

Replicative Cell Senescence

4.5K
Replicative cell senescence is a property of cells that allows them to divide a finite number of times throughout the organism's lifespan while preventing excessive proliferation. Replicative senescence is associated with the gradual loss of the telomere — short, repetitive DNA sequences found at the end of the chromosomes. Telomeres are bound by a group of proteins to form a protective cap on the ends of chromosomes. Embryonic stem cells express telomerase — an enzyme that adds...
4.5K
The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

3.9K
Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
3.9K
Exercise and Cardiovascular Response01:20

Exercise and Cardiovascular Response

4.7K
Exercise significantly impacts cardiovascular response, which is crucial for understanding patient health and designing effective treatment plans.
Light to moderate physical activity initiates a series of interconnected responses in the body. The heart rate modestly increases in anticipation of the workout, followed by widespread vasodilation as oxygen consumption by skeletal muscles increases. This results in decreased peripheral resistance, increased capillary blood flow, and accelerated...
4.7K
Exercise and Muscle Performance01:27

Exercise and Muscle Performance

2.8K
Exercise induces a range of adaptations in muscle tissue, depending on the type and duration of activity. Such physical training can be broadly categorized into two types: endurance exercises and resistance exercises.
Endurance exercises
Endurance exercises involve running, swimming, or cycling, which require repetitive movements with low force output. When a person engages in endurance exercise, a few noticeable changes occur in their skeletal muscles. For instance, the number of capillaries...
2.8K
Mitochondria01:37

Mitochondria

21.0K
Mitochondria are eukaryotic cellular organelles that are known to produce energy through a process called oxidative phosphorylation. Besides their primary function, mitochondria are involved in various cellular processes, including cell growth, differentiation, signaling, metabolism, and senescence. Age-related changes cause a decline in mitochondrial quality and integrity due to increased mitochondrial mutations and oxidative damage. Thus, aging can severely impact mitochondrial functions,...
21.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Ex vivo heart perfusion induces time dependent inflammatory activation in human donor hearts.

NPJ cardiovascular health·2026
Same author

Long noncoding RNA SALTe1, microvascular ageing, and cardiac dysfunction.

European heart journal·2026
Same author

Large-scale identification of protein biomarkers and therapeutic targets in heart and brain disease.

Nature cardiovascular research·2026
Same author

Large-Scale Identification of Novel Protein Biomarkers and Therapeutic Targets in Heart and Brain Disease.

medRxiv : the preprint server for health sciences·2026
Same author

p16<sup>INK4a</sup> promotes myocardial ischemia-reperfusion injury by regulating bile acid transport via Slco1a4.

EMBO reports·2026
Same author

Sensory-neuron-derived CGRPα controls white adipocyte differentiation and tissue plasticity.

Cell reports·2025

Related Experiment Video

Updated: Feb 24, 2026

A Quantitative Measurement of Reactive Oxygen Species and Senescence-associated Secretory Phenotype in Normal Human Fibroblasts During Oncogene-induced Senescence
13:59

A Quantitative Measurement of Reactive Oxygen Species and Senescence-associated Secretory Phenotype in Normal Human Fibroblasts During Oncogene-induced Senescence

Published on: August 12, 2018

8.6K

Circulating Senescence Protein Links Exercise Adaptation to Health Outcomes.

Nicholas Houstis, Qiulian Zhou, Yuling Chen

    Medrxiv : the Preprint Server for Health Sciences
    |February 23, 2026
    PubMed
    Summary
    This summary is machine-generated.

    Individual exercise capacity gains vary due to molecular factors. Researchers found insulin-like growth factor binding protein-7 (IGFBP7) limits fitness improvements from exercise, impacting healthspan.

    More Related Videos

    Measurement of Protein Turnover Rates in Senescent and Non-Dividing Cultured Cells with Metabolic Labeling and Mass Spectrometry
    08:52

    Measurement of Protein Turnover Rates in Senescent and Non-Dividing Cultured Cells with Metabolic Labeling and Mass Spectrometry

    Published on: April 6, 2022

    4.1K
    Evaluation of Injury-induced Senescence and In Vivo Reprogramming in the Skeletal Muscle
    09:14

    Evaluation of Injury-induced Senescence and In Vivo Reprogramming in the Skeletal Muscle

    Published on: October 26, 2017

    10.1K

    Related Experiment Videos

    Last Updated: Feb 24, 2026

    A Quantitative Measurement of Reactive Oxygen Species and Senescence-associated Secretory Phenotype in Normal Human Fibroblasts During Oncogene-induced Senescence
    13:59

    A Quantitative Measurement of Reactive Oxygen Species and Senescence-associated Secretory Phenotype in Normal Human Fibroblasts During Oncogene-induced Senescence

    Published on: August 12, 2018

    8.6K
    Measurement of Protein Turnover Rates in Senescent and Non-Dividing Cultured Cells with Metabolic Labeling and Mass Spectrometry
    08:52

    Measurement of Protein Turnover Rates in Senescent and Non-Dividing Cultured Cells with Metabolic Labeling and Mass Spectrometry

    Published on: April 6, 2022

    4.1K
    Evaluation of Injury-induced Senescence and In Vivo Reprogramming in the Skeletal Muscle
    09:14

    Evaluation of Injury-induced Senescence and In Vivo Reprogramming in the Skeletal Muscle

    Published on: October 26, 2017

    10.1K

    Area of Science:

    • Exercise physiology
    • Molecular biology
    • Aging research

    Background:

    • Physiological stress adaptation and health vary significantly between individuals.
    • Heterogeneity in human fitness gains from identical exercise training is well-documented but poorly understood at a molecular level.
    • Identifying molecular determinants of exercise "trainability" is crucial for understanding healthspan.

    Purpose of the Study:

    • To identify circulating molecular factors that constrain exercise adaptation.
    • To investigate the role of insulin-like growth factor binding protein-7 (IGFBP7) in regulating physiological plasticity in response to exercise.
    • To explore the association between IGFBP7 levels, exercise responsiveness, and health outcomes.

    Main Methods:

    • Plasma proteomics analysis in older adults undergoing a randomized high-intensity interval training trial.
    • Genetic manipulation (knockout and overexpression) of IGFBP7 in mice to assess exercise capacity.
    • Association studies using UK Biobank data linking IGFBP7 levels to mortality and age-related diseases.

    Main Results:

    • Elevated plasma IGFBP7 levels inversely correlated with fitness gains after one year of high-intensity interval training.
    • Genetic deletion of IGFBP7 in mice significantly enhanced training-induced improvements in exercise capacity.
    • Somatic overexpression of IGFBP7 in mice abolished exercise training benefits.
    • Lower IGFBP7 levels in the UK Biobank cohort were linked to reduced mortality and fewer incident age-related diseases.

    Conclusions:

    • Circulating IGFBP7 acts as a molecular brake on physiological adaptation to exercise.
    • IGFBP7 links exercise training responsiveness, aging biology, and overall healthspan.
    • Targeting IGFBP7 could potentially enhance exercise benefits and improve health outcomes.