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Updated: Feb 24, 2026

Evidence-based Knowledge Synthesis and Hypothesis Validation: Navigating Biomedical Knowledge Bases via Explainable AI and Agentic Systems
Published on: June 13, 2025
Explainable AI for Healthcare
Yupei Li1, Qiyang Sun1, Alican Akman1
1GLAM - Group on Language, Audio, & Music, Imperial College London, UK.
Explainable AI (XAI) is crucial for trustworthy healthcare applications. XAI enhances transparency in artificial intelligence (AI) models, improving clinical decisions and patient trust.
Area of Science:
- Computer Science
- Artificial Intelligence
- Healthcare Technology
Background:
- Artificial intelligence (AI) integration in healthcare is rapidly advancing, impacting diagnosis, treatment, and patient care.
- Complex AI models often lack transparency, posing risks in high-stakes medical decision-making.
- Explainability is vital for informed clinical decisions and patient trust in AI.
Purpose of the Study:
- To introduce foundational concepts of explainable AI (XAI).
- To analyze XAI methodologies for enhancing AI model interpretability in healthcare.
- To discuss XAI applications across diverse healthcare data modalities.
Main Methods:
- Review of foundational explainable AI (XAI) concepts.
- Analysis of prominent methodologies for enhancing AI model interpretability.
- Examination of XAI applications across time-series, text, image, and audio medical data.
Main Results:
- XAI provides transparency essential for healthcare professionals and patients.
- XAI addresses unique challenges across various medical data types.
- Identified prominent XAI methodologies applicable to healthcare domains.
Conclusions:
- XAI is critical for safe and effective AI implementation in healthcare.
- Current limitations and challenges in healthcare XAI implementation were discussed.
- Promising future research directions for enhancing AI reliability in healthcare were identified.
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