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Updated: Feb 24, 2026

Knee Arthrocentesis in Adults
Published on: February 25, 2022
Should Arthrocentesis Be Performed in the Noneffusive Knee?
Rosemina A Patel1, Matthew K McElwee2, Chantalle D Geller3
1Presbyterian Healthcare Services, Albuquerque, NM.
Pneumatic compression significantly improves knee joint fluid aspiration success in noneffusive knees. This method yields diagnostically useful synovial fluid, aiding in the evaluation of various knee conditions.
Area of Science:
- Orthopedic Surgery
- Rheumatology
- Diagnostic Procedures
Background:
- Arthrocentesis of a knee joint without effusion is technically difficult.
- A reliable method to obtain synovial fluid from such joints is needed for accurate diagnosis.
Purpose of the Study:
- To evaluate the efficacy of pneumatic compression in improving arthrocentesis success in noneffusive knees.
- To determine if the increased synovial fluid yield is diagnostically valuable.
Main Methods:
- 130 patients with clinically noneffusive knees underwent arthrocentesis with and without pneumatic compression.
- Fluid volume was measured, and success was defined as ≥1.0 mL yield.
- Synovial fluid was analyzed for cell counts, crystal presence, and bacterial culture.
Main Results:
- Arthrocentesis success increased from 15.4% to 53.8% with pneumatic compression (p=0.0001).
- Pneumatic compression increased fluid yield by 460% (0.5 mL to 2.8 mL).
- 60% of aspirated fluids were abnormal, revealing inflammatory arthritis, noninflammatory arthritis, or crystal disease.
Conclusions:
- Pneumatic compression-assisted arthrocentesis successfully yields synovial fluid from clinically noneffusive knees.
- The collected fluid is often abnormal, aiding in diagnosing various joint conditions.
- This technique is valuable for evaluating symptomatic, noneffusive knees.
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