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Comparative Evaluation of Topical Stabilized Retinaldehyde 0.1% vs. 0.05% on Skin Biophysical and Biomechanical
Anna Deda1, Wiktoria Odrzywołek2, Agata Lebiedowska2
1Department of Practical Cosmetology and Skin Diagnostics, Faculty of Pharmaceutical Sciences in Sosnowiec, Medical University of Silesia in Katowice, Sosnowiec, Poland.
Background:
The aim of this study was to evaluate the biophysical and biomechanical effects of topical stabilized retinaldehyde (RAL) treatments on skin, using different concentrations of retinal (0.05% and 0.1%).
Materials And Methods:
Employing a split-face design and noninvasive methods such as high-frequency ultrasonography, the Antera 3D camera, and the Cutometer, the effectiveness of these preparations was assessed among 56 women aged 30-58 years.
Results:
The application of topical stabilized RAL resulted in statistically significant improvements in skin parameters. High-frequency ultrasonography revealed increased dermal density across all facial regions after 24 weeks, while Cutometer measurements showed enhanced skin elasticity and viscoelasticity. Antera 3D imaging demonstrated significant reductions in wrinkle parameters, particularly with the higher concentration (0.1%) of RAL. The treatments were generally well-tolerated, with minimal adverse effects reported, highlighting their suitability for sensitive skin.
Conclusion:
Results indicated significant improvements in skin texture and firmness, particularly with the higher 0.1% concentration of RAL over 24-week period, making it a promising option for long-term skin rejuvenation therapy.
