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Assessment of Chimeric Antigen Receptor T Cell-Associated Toxicities Using an Acute Lymphoblastic Leukemia Patient-Derived Xenograft Mouse Model
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Infection prophylaxis following anti-CD20 monoclonal antibodies in childhood kidney diseases

Dongyang Zhou1, Fiona Fung-Yee Lai2, Joshua Sung-Chih Wong3

  • 1Department of Paediatrics, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong SAR.

Pediatric Nephrology (Berlin, Germany)
|February 23, 2026
PubMed

Anti-CD20 monoclonal antibodies (mAbs), which act as B-cell-depleting therapies, are now regarded as important treatments for a range of paediatric kidney diseases. Despite their effectiveness in achieving B-cell depletion and consequent disease remission, concerns remain regarding their side effect profile. These include infusion reactions, hypogammaglobulinaemia, and neutropenia, as well as infections. At present, the evidence supporting preventive measures such as intravenous immunoglobulin (IVIG) replacement and antibiotic prophylaxis remains inconclusive. In this review, we summarise the existing data on infection-related risks following anti-CD20 therapy and propose practical strategies to mitigate infection risk tailored to this group of children.

Keywords:
Anti-CD20ChildrenInfectionKidney diseasesObinutuzumabRituximab

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