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Updated: Feb 24, 2026

In Vivo, Percutaneous, Needle Based, Optical Coherence Tomography of Renal Masses
Published on: March 30, 2015
Contrast-enhanced ultrasound of renal collecting duct carcinoma: first report of quantitative microvascular
Xueyan Wang1,2,3, Xiangmin Shen4,5, Chengcheng Niu1,2,3
1Department of Ultrasound Diagnosis, The Second Xiangya Hospital, Central South University, 139 Renmin Road, Changsha, 410011, Hunan, China.
Objectives:
To characterize the contrast-enhanced ultrasound (CEUS) features of collecting duct carcinoma (CDC) with quantitative hemodynamic analysis.
Methods:
A 28-year-old male with painless hematuria underwent CEUS (SonoVue®; MI = 0.07). Time-intensity curve (TIC) analysis was performed using Contrast Dynamics software.
Results:
CEUS revealed: (1) Heterogeneous arterial enhancement (10 s): Central hyperenhancement (peak SI 37.5%) with peripheral hypoenhancement. (2) Aggressive kinetics: TTP 30 s, wash-out onset 35 s. (3)Absent pseudocapsule sign. Pathology confirmed CDC (Vimentin + /34βE12 + /CK7-/CD10-).
Conclusion:
This first comprehensive CEUS analysis of CDC demonstrates its unique microvascular phenotype-characterized by abnormal perfusion kinetics and absent pseudocapsule sign correlating with histologic aggressiveness. CEUS enhances CDC diagnosis when combined with immunohistochemistry.
Advances In Knowledge:
This study provides the first quantitative CEUS hemodynamic profile of CDC, identifying a diagnostic triad of heterogeneous enhancement, absent pseudocapsule, and "fast-in-fast-out" kinetics correlating with histologic aggressiveness. We demonstrate that integrating CEUS microvascular phenotyping with immunohistochemistry enhances diagnostic precision for this rare malignancy.
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