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Updated: Jun 3, 2026

Biocytin Recovery and 3D Reconstructions of Filled Hippocampal CA2 Interneurons
Published on: November 20, 2018
Co-simulation framework combining a microscopically detailed point neuron model of the hippocampal CA1 region with
Lorenzo Tartarini1, Paul Triebkorn2, Lionel Kusch2
1Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy.
Abstract:
The human brain is a complex adaptive system characterized by dynamic processes operating across multiple spatio-temporal scales. Capturing these dynamics requires computational models that can integrate different levels of resolution. In this work we present a multiscale co-simulation framework that couples whole-brain modeling with a detailed point-neuron model of the human hippocampal CA1 region. We used a high-resolution implementation of the "The Virtual Brain" (TVB), in which cortical surface mesh vertices are embedded with the Spatial Epileptor Model (SEM). At the microscale, the CA1 model captures neuronal activity at micrometer spatial and sub-millisecond temporal resolution. This integration enables the simulation of macroscale epileptic dynamics with microscale neuronal precision within anatomically grounded brain regions, facilitating cross-scale communication. These results demonstrate the potential of this approach to advance mechanism-driven, personalized medicine in clinical neuroscience.
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