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Physiological pharmacokinetic models, often called flow-limited or perfusion models, typically assume a swift drug distribution between tissue and venous blood, creating a rapid drug equilibrium. This premise is based on the idea that drug diffusion is extremely fast, and the cell membrane presents no barrier to drug permeation. In this scenario, where no drug binding occurs, the drug concentration in the tissue equals that of the venous blood leaving the tissue. This greatly simplifies the...
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Updated: Feb 25, 2026

A Method for Determination and Simulation of Permeability and Diffusion in a 3D Tissue Model in a Membrane Insert System for Multi-well Plates
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Beyond Heat Dissipation: Optimizing Diffusion Models in Frequency Domain.

Qisen Wang, Yifan Zhao, Jia Li

    IEEE Transactions on Pattern Analysis and Machine Intelligence
    |February 23, 2026
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    Summary
    This summary is machine-generated.

    This study introduces Frequency Inductive Biases Bootstrapping Optimization (FIBBO) to enhance generalized diffusion models. FIBBO improves image generation quality by adaptively adjusting frequency degradation during training.

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    Area of Science:

    • Artificial Intelligence
    • Computer Vision
    • Machine Learning

    Background:

    • Standard diffusion models often use pixel-wise degradations, ignoring image multi-scale characteristics.
    • Generalized diffusion models with Positive Semi-definite Degradations (PSD) address this but face generation quality issues due to fixed inductive biases and incomplete optimization analysis.

    Purpose of the Study:

    • To provide a comprehensive theoretical analysis of the optimization process in the frequency domain for PSD-based generalized diffusion models.
    • To propose a novel method that addresses the limitations of hand-crafted and fixed inductive biases in existing models.

    Main Methods:

    • Developed a theoretical analysis of the frequency domain optimization for PSD-based generalized diffusion models.
    • Proposed the Frequency Inductive Biases Bootstrapping Optimization (FIBBO) method.
    • FIBBO parameterizes the forward process and adaptively modifies the non-isotropic Gaussian kernel during training.

    Main Results:

    • Demonstrated that the forward process of PSD models implicitly influences inductive biases in the reverse process optimization.
    • FIBBO enables learning distinct frequency degradation-generation trajectories iteratively.
    • Experiments show significant improvements in generation quality for PSD-based generalized diffusion models.

    Conclusions:

    • FIBBO effectively tackles the limitations of hand-crafted and fixed inductive biases in PSD-based diffusion models.
    • The adaptive nature of FIBBO enhances the model's performance across different data distributions.
    • The proposed method offers a promising direction for improving generalized diffusion models.