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Updated: Feb 25, 2026

Rapid Detection of Neurodevelopmental Phenotypes in Human Neural Precursor Cells NPCs

Rapid Detection of Neurodevelopmental Phenotypes in Human Neural Precursor Cells NPCs

Published on: March 2, 2018

Methods for Elucidating Disease Mechanisms in Neurodevelopmental Disorders.

Ashley B Durbin¹, Philip H Iffland²

¹Department of Neurology, University of Maryland School of Medicine.

Journal of Visualized Experiments : Jove

|February 23, 2026

Summary

This summary is machine-generated.

New gene editing and stem cell technologies offer hope for understanding and treating neurodevelopmental disorders (NDDs). These advanced methods are crucial for discovering new disease mechanisms and therapeutic targets for millions affected globally.

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Area of Science:

Neuroscience
Genetics
Developmental Biology

Background:

Neurodevelopmental disorders (NDDs) impact 317 million children globally.
Common outcomes include epilepsy, autism spectrum disorder (ASD), and intellectual disability (ID).
Current treatments lack disease-modifying capabilities and cures.

Purpose of the Study:

To review novel methods for understanding NDDs.
To explore gene editing, stem cell models, and functional variant validation.
To bridge the gap between research and clinical application for NDDs.

Main Methods:

Gene editing technologies for disease modeling and potential therapy.
Stem cell-derived models for studying NDD pathogenesis.
Cellular and molecular assays for variant functional validation.

Main Results:

Gene editing shows promise for understanding NDDs and has achieved clinical success.
Stem cell models provide precise human disease process modeling.
Novel methods aid in categorizing genetic variants and uncovering disease mechanisms.

Conclusions:

Advanced techniques like gene editing and stem cell models are vital for NDD research.
These methods facilitate the discovery of novel therapeutic targets.
Translating bench research to clinical practice is essential for improving NDD outcomes.