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Updated: Feb 25, 2026
18:48
In Vitro and In Vivo Assessment of T, B and Myeloid Cells Suppressive Activity and Humoral Responses from Transplant Recipients
Published on: August 12, 2017
15.0K
The DC1 conundrum: Do type I dendritic cells make or break allograft tolerance?
Ivana R Shen1, Shareni Jeyamogan2, Rebecca T L Jones1
1Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
Summary
Type 1 conventional dendritic cells (DC1s) show a dual role in solid organ transplantation (SOT) tolerance. Emerging research highlights their potential as a novel cellular therapy for SOT, improving allograft survival without immunosuppression.
Area of Science:
- Immunology
- Transplantation Biology
- Cellular Therapy
Background:
- Solid organ transplantation (SOT) aims for long-term allograft survival without immunosuppression through immunological tolerance.
- Type 1 conventional dendritic cells (DC1s) are crucial for self-tolerance and have a complex role in allo-tolerance.
- Previous research primarily focused on monocyte-derived dendritic cells (moDCs) for tolerance induction.
Purpose of the Study:
- To review the dual role of DC1s in promoting and hindering allo-tolerance in SOT.
- To explore the impact of tissue microenvironment and cellular interactions on DC1 function.
- To discuss the potential of DC1s as a novel cellular therapy for SOT.
Main Methods:
- Review of existing literature on DC1 biology and function in transplantation.
- Analysis of recent advances in dendritic cell research and ontogeny.
- Examination of early-phase clinical trial data for DC-based cellular therapies in SOT.
Main Results:
- DC1s exhibit context-dependent functions, influencing both tolerance and rejection in SOT.
- Tissue microenvironment, antigen load, and cellular crosstalk modulate DC1 activity.
- Early clinical trials show promising safety and efficacy for tolerogenic DC therapy in SOT.
Conclusions:
- DC1s possess a subset-specific, tolerogenic capacity relevant to SOT.
- Understanding the complex functions of DC1s is key to developing effective cellular therapies.
- DC1-based cellular therapy represents a promising avenue for improving SOT outcomes.
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