Emerging nanocarrier platforms in Cervical cancer therapy: From Molecular targeting to Precision Nanomedicine

Area of Science:

• Biomedical Engineering
• Nanotechnology
• Oncology

Background:

• Cervical cancer presents a significant global health challenge.
• Conventional treatments (surgery, chemotherapy, radiotherapy) have limitations including poor tumor specificity, systemic toxicity, and infertility.
• Advanced, targeted nanocarrier-based drug delivery systems are needed for improved cervical cancer therapy.

Purpose of the Study:

• To review recent advancements in nanocarrier platforms for cervical cancer therapy.
• To systematically analyze various nanocarrier types and their therapeutic performance.
• To highlight the potential of nanocarriers in enhancing treatment efficacy and patient outcomes.

Main Methods:

• Systematic review of preclinical and clinical studies on nanocarrier platforms for cervical cancer.
• Analysis of diverse nanocarriers including solid lipid nanoparticles, dendrimers, carbon nanotubes, hydrogels, albumin-based nanoparticles, niosomes, surface-functionalized systems, and plant-derived vesicles.
• Evaluation of drug-loading capacity, targeting efficiency, and therapeutic performance of nanocarriers.

Main Results:

• Nanocarriers exhibit enhanced tumor targeting through active, passive, and stimuli-responsive mechanisms.
• Co-delivery of chemotherapeutics with gene silencing agents, photothermal/magnetic agents, and ligands improves cellular uptake and overcomes multidrug resistance.
• Nanocarriers facilitate real-time monitoring and theranostics, integrating diagnosis and treatment for cervical cancer.

Conclusions:

• Nanocarrier-based drug delivery represents a transformative approach for cervical cancer management, offering safer, more effective, and personalized options.
• Challenges remain in large-scale manufacturing, in-vivo stability, long-term safety, and regulatory compliance.
• Continued advancements and interdisciplinary collaboration are crucial for clinical translation and precision medicine in cervical cancer care.