Related Experiment Video

Updated: Feb 25, 2026

Digital Home-Monitoring of Patients after Kidney Transplantation: The MACCS Platform
07:13

Digital Home-Monitoring of Patients after Kidney Transplantation: The MACCS Platform

Published on: April 12, 2021

5.3K

Mitigating Risk of Kidney Dysfunction After Heart Transplantation and Therapeutic Approaches

Ersilia M DeFilippis1, Richard K Cheng2, Elena M Donald1

  • 1Department of Medicine, Center for Advanced Cardiac Care, Division of Cardiology, New York Presbyterian-Columbia University Irving Medical Center (E.M. DeFilippis, E.M. Donald).

Circulation. Heart Failure
|February 23, 2026
PubMed

Insights

Kidney dysfunction after heart transplantation (HT) is a growing concern, impacting patient survival. This review explores kidney injury risks, mitigation strategies, and future directions for heart transplant recipients.

Area of Science:

  • Nephrology
  • Cardiology
  • Transplantation Medicine

Background:

  • Kidney dysfunction is a significant complication following heart transplantation (HT), leading to increased morbidity and mortality.
  • The incidence of acute and chronic kidney dysfunction is rising post-2018 US allocation system, linked to mechanical support use and altered recipient profiles.
  • Existing nephroprotective therapies for chronic kidney disease in heart failure patients show promise, but data in HT recipients are emerging.

Purpose of the Study:

  • To review the epidemiology of kidney dysfunction after heart transplantation.
  • To examine mitigation strategies for acute kidney injury and chronic kidney disease in HT recipients.
  • To discuss the need for kidney transplantation post-HT and outline future research directions.

Main Methods:

  • Systematic literature review of existing studies on kidney dysfunction post-heart transplantation.
  • Critical analysis of epidemiological data, risk factors, and outcomes.
  • Evaluation of current and emerging pharmacotherapeutic and non-pharmacotherapeutic interventions.

Main Results:

  • Kidney dysfunction is a prevalent and increasing issue after heart transplantation.
  • Recipient and perioperative factors significantly influence the risk of kidney injury.
  • Emerging data suggest potential benefits of certain nephroprotective agents in HT recipients.

Conclusions:

  • Kidney dysfunction poses a substantial threat to heart transplant recipients, necessitating focused attention.
  • Proactive strategies for preventing and managing kidney injury are crucial.
  • Further research is needed to optimize kidney care and transplantation outcomes in this population.

Keywords:
dialysisheart failureheart transplantationkidney diseasekidney transplantation

More Related Videos

5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats05:34

5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats

Published on: April 4, 2025

1.8K
Orthotopic Rat Kidney Transplantation: A Novel and Simplified Surgical Approach09:15

Orthotopic Rat Kidney Transplantation: A Novel and Simplified Surgical Approach

Published on: May 7, 2019

17.1K

Related Concept Videos

Kidney Transplant I: Introduction01:28

Kidney Transplant I: Introduction

A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
562
Kidney Transplant III: Nursing Management01:16

Kidney Transplant III: Nursing Management

Postoperative Nursing Management for Kidney Transplant PatientsPostoperative nursing management care includes monitoring the surgical site, encouraging early movement, and promoting lung health through breathing exercises. Nurses also administer prescribed medications like H2-blockers, such as famotidine, or proton pump inhibitors, like omeprazole, to help prevent gastrointestinal ulcers and bleeding. Fungal infections in the mouth and bladder can result from immunosuppressive and antibiotic...
436
Kidney Transplant II: Surgical Procedure01:26

Kidney Transplant II: Surgical Procedure

Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living...
527
Heart Failure Drugs: Inhibitors of Renin-Angiotensin System01:26

Heart Failure Drugs: Inhibitors of Renin-Angiotensin System

The activation of the sympathetic nervous system and the renin-angiotensin-aldosterone system (RAAS) contributes to cardiac remodeling, and inhibiting the RAAS is a pharmacological target in heart failure management. As a result, neurohumoral modulation is a crucial treatment principle for managing heart failure. This approach involves using medications like ACE inhibitors (ACEIs), angiotensin receptor blockers (ARBs), β-blockers, mineralocorticoid receptor antagonists (MRAs), and neutral...
1.3K
Acute Kidney Injury IV: Diagnostic Studies and Prevention01:30

Acute Kidney Injury IV: Diagnostic Studies and Prevention

Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
370
Heart Failure Drugs: Diuretics01:22

Heart Failure Drugs: Diuretics

Heart failure and kidney perfusion are interconnected in a complex way. Reduced renal perfusion and venous congestion are two significant factors that contribute to renal dysfunction in heart failure. The kidneys, primarily responsible for fluid balance in the body, are adversely affected due to compromised cardiac output and increased venous pressure. In response to reduced renal perfusion, the kidneys activate neurohumoral mechanisms to restore balance. However, these mechanisms can be...
1.1K