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100 years of childhood acute lymphoblastic leukaemia in the UK

Helen Lane1, John Moppett2

  • 1Paediatric Haematology, Bristol Royal Hospital for Children, Bristol, UK.

Archives of Disease in Childhood
|February 23, 2026
PubMed

Insights

Over the last century, UK paediatric acute lymphoblastic leukaemia care has seen significant advancements. UK trials have been pivotal in improving treatment outcomes for children with this condition.

Area of Science:

  • Paediatric Oncology
  • Clinical Trials
  • Leukemia Research

Background:

  • Acute lymphoblastic leukaemia (ALL) is a significant childhood cancer.
  • Historically, outcomes for paediatric ALL were poor.
  • Advances in treatment have dramatically improved survival rates.

Purpose of the Study:

  • To review 100 years of paediatric ALL care development in the UK.
  • To highlight the role of UK ALL clinical trials.
  • To showcase improvements in patient care and outcomes.

Main Methods:

  • Historical review of paediatric ALL care in the UK.
  • Analysis of contributions from UK Acute lymphoblastic leukaemia trials.
  • Summary of treatment evolution and supportive care enhancements.

Main Results:

  • Demonstrable progress in paediatric ALL treatment protocols over a century.
  • Significant impact of UK ALL trials on therapeutic strategies.
  • Marked improvements in survival rates and quality of life for paediatric patients.

Conclusions:

  • UK clinical trials have been instrumental in advancing paediatric ALL care.
  • Continued research and collaborative trials are essential for further progress.
  • The journey of paediatric ALL care in the UK represents a major success in paediatric oncology.

Keywords:
History Of MedicinePaediatrics

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