Evaluation of the Neuropathic Component of Pain in Sickle Cell Disease

Pain is the defining factor of sickle cell disease (SCD), an inherited blood disorder. A cross-sectional study on the prevalence of the neuropathic component of pain in the Indian tribal population was conducted from August 2024 to June 2025 in Mysuru and Chamarajanagar districts, Karnataka. Forty eight individuals (aged ≥10 years, mean age 26 years) with the HbSS genotype were assessed using the painDETECT questionnaire, translated and adapted for local use. 48% exhibited painDETECT scores suggestive of a neuropathic pain component. 29.2% had a definitive neuropathic component and 18.8% had a probable neuropathic component. 35.4% of patients reported a pain pattern consistent with neuropathic features (pain attacks with/without pain between them). Pain radiation, a feature of neuropathic pain, was reported by 70.8% of individuals. No significant associations were found between neuropathic pain scores and age or gender. Our study highlights the prevalence of the neuropathic component of pain in SCD in the Jenu Kuruba and Soligas tribal populations of India. Further research is necessary to identify a standardized pain evaluation tool for this population. Individualized culturally sensitive, neuropathic pain specific interventions could significantly improve pain control and the quality of life in this underserved population.