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Intravesical Gentamicin for Prevention of Recurrent Urinary Tract Infections in Patients With Neurogenic Lower
Lucas Antonio Pereira do Nascimento1, Vicktor Bruno Pereira Pinto1, Luiz Guilherme Serrão Gimenez1
1School of Medicine, Division of Urology, University of Sao Paulo, Sao Paulo, Brazil.
Neurourology and Urodynamics
|February 23, 2026
Summary
Intravesical gentamicin (IVG) effectively prevents recurrent urinary tract infections (rUTIs) in neurogenic lower urinary tract dysfunction (NLUTD) patients undergoing clean intermittent catheterization (CIC). This method shows high safety and reduces antibiotic use, though more research is needed.
Area of Science:
- Urology
- Infectious Diseases
- Pharmacology
Background:
- Patients with neurogenic lower urinary tract dysfunction (NLUTD) undergoing clean intermittent catheterization (CIC) face a high risk of recurrent urinary tract infections (rUTIs).
- Oral antibiotic prophylaxis for rUTI prevention is often ineffective and contributes to antimicrobial resistance.
- Intravesical gentamicin (IVG) presents a potential alternative, but existing evidence is limited and varied.
Conclusions:
- Intravesical gentamicin (IVG) is a safe and effective prophylactic option for preventing rUTIs in NLUTD patients using CIC.
- The current evidence base is limited by a small number of studies, varied protocols, and a lack of randomized controlled trials.
- Further high-quality research is necessary to establish standardized IVG regimens for widespread clinical use.
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