Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Allogeneic CD70-Targeted Chimeric Antigen Receptor T-Cell Therapy for Advanced Renal Cell Carcinoma: Results From the Phase I TRAVERSE Trial.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology·2026
Same author

Tartrazine Clears Live Cells while Preserving Viability at High Refractive Indices and Osmolality.

Bioconjugate chemistry·2026
Same author

Review on the Mechanism of and Therapies Targeting PANoptosis in Ulcerative Colitis.

Biomolecules·2026
Same author

On-demand formation of ultrathin liquid metal hydrogel tattoos for conformal and low-impedance bioelectronics.

Science advances·2026
Same author

Rapid rescue of despair behaviors by sonogenetic neuromodulation of the mPFC-DRN pathway.

Molecular psychiatry·2026
Same author

[Molecular mechanisms and clinical applications of anti-angiogenic therapy in precision treatment of breast cancer].

Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences·2026

Related Experiment Video

Updated: Feb 25, 2026

Author Spotlight: Integration of Fiber Photometry and Focused Ultrasound Neuromodulation for Investigating Neural Modulation in Freely Moving Mice
08:38

Author Spotlight: Integration of Fiber Photometry and Focused Ultrasound Neuromodulation for Investigating Neural Modulation in Freely Moving Mice

Published on: September 6, 2024

2.2K

Sono-mechanical nanostructures-enabled sustained precise ultrasound brain stimulation.

Xuandi Hou1, Jianing Jing1, Zhuohan Shi1

  • 1Department of Biomedical Engineering, The Hong Kong Polytechnic University, Hong Kong, China.

Nature Communications
|February 23, 2026
PubMed
Summary

Researchers developed hollow silica nanostructures (HSN) for precise deep brain neuromodulation using ultrasound. This method activates targeted neurons, showing potential for treating Parkinson's disease symptoms in mice without genetic modification.

More Related Videos

Multiplexing Focused Ultrasound Stimulation with Fluorescence Microscopy
08:39

Multiplexing Focused Ultrasound Stimulation with Fluorescence Microscopy

Published on: January 7, 2019

8.7K
A Methodological Protocol and Considerations for Transcranial Ultrasonic Stimulation in Exploratory Clinical Human Studies
09:47

A Methodological Protocol and Considerations for Transcranial Ultrasonic Stimulation in Exploratory Clinical Human Studies

Published on: December 12, 2025

337

Related Experiment Videos

Last Updated: Feb 25, 2026

Author Spotlight: Integration of Fiber Photometry and Focused Ultrasound Neuromodulation for Investigating Neural Modulation in Freely Moving Mice
08:38

Author Spotlight: Integration of Fiber Photometry and Focused Ultrasound Neuromodulation for Investigating Neural Modulation in Freely Moving Mice

Published on: September 6, 2024

2.2K
Multiplexing Focused Ultrasound Stimulation with Fluorescence Microscopy
08:39

Multiplexing Focused Ultrasound Stimulation with Fluorescence Microscopy

Published on: January 7, 2019

8.7K
A Methodological Protocol and Considerations for Transcranial Ultrasonic Stimulation in Exploratory Clinical Human Studies
09:47

A Methodological Protocol and Considerations for Transcranial Ultrasonic Stimulation in Exploratory Clinical Human Studies

Published on: December 12, 2025

337

Area of Science:

  • Neuroscience
  • Biotechnology
  • Materials Science

Background:

  • Transcranial ultrasound offers high spatiotemporal resolution for neuromodulation.
  • Conventional ultrasound lacks precision for targeting small neuronal populations.
  • Existing neuromodulation techniques like TMS, tDCS, and tACS have limitations.

Purpose of the Study:

  • To enhance the precision and efficacy of ultrasound-based neuromodulation.
  • To develop a method for long-term, targeted deep brain stimulation.
  • To investigate the therapeutic potential for neurological disorders like Parkinson's disease.

Main Methods:

  • Introduction of hollow silica nanostructures (HSN) to localize and amplify ultrasound effects.
  • Delivery of HSN to specific brain regions (M1, striatum, VTA, STN) in male mice.
  • Activation of mechanosensitive ion channels via ultrasound stimulation.
  • Assessment of motor symptom relief and toxicity in a Parkinson's disease mouse model.

Main Results:

  • HSN enabled selective and long-term neuromodulation of targeted brain regions.
  • Ultrasound stimulation with HSN effectively relieved motor symptoms in Parkinson's disease mice.
  • The approach demonstrated minimal invasiveness and no evident toxicity.
  • Targeted activation was achieved at time points ranging from days to weeks post-delivery.

Conclusions:

  • Hollow silica nanostructures provide a safe and effective strategy for precise, chronic neuromodulation.
  • This ultrasound-based approach offers therapeutic potential for neurological conditions without genetic modification.
  • The technology advances minimally-invasive deep brain stimulation techniques.