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Updated: Feb 25, 2026

In vitro Enrichment of Ovarian Cancer Tumor-initiating Cells
Published on: February 18, 2015
A case of ovarian Sertoli-Leydig cell tumor with high grade transformation harbouring DICER1 and TP53 mutations
Kristýna Němejcová1, Eva Horváthová2, Michaela Kendall Bártů2
1Department of Pathology, First Faculty of Medicine, Charles University and General University Hospital in Prague, Studničkova 2, 12800, Prague, Czech Republic. Kristyna.Nemejcova@vfn.cz.
Abstract:
Sertoli-Leydig cell tumor (SLCT) is a rare ovarian sex cord-stromal tumor that may occur sporadically or in the context of DICER1 syndrome. We present a case of ovarian SLCT with high-grade transformation in a 73-year-old patient. The tumor showed typical morphology and immunophenotype of moderately differentiated SLCT with distinct areas of high-grade transformation. NGS DNA sequencing revealed two somatic DICER1 mutations. In addition, a pathogenic TP53 mutation was detected exclusively in the high-grade area. This case represents only the second documented ovarian SLCT with confirmed high-grade transformation supported by a concurrent TP53 alteration.
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