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Updated: Feb 25, 2026

Integration of Wet and Dry Bench Processes Optimizes Targeted Next-generation Sequencing of Low-quality and Low-quantity Tumor Biopsies
Published on: April 11, 2016
Integrating liquid biopsy and mutational signatures to advance precision oncology
Raquel Carrasco1, Kristian Dreij2
1Institute of Environmental Medicine, Karolinska Institutet, Solna, Sweden. raquel.carrasco.romo@ki.se.
Abstract:
The effective application of precision oncology in solid tumors remains challenging due to genetic heterogeneity and the absence of actionable alterations in some cancers. In this review, we discuss the integration of liquid biopsy and mutational signatures as a potential framework to address these limitations by enabling longitudinal detection of mutational processes that arise during tumor development and evolution. Together, these complementary approaches hold substantial promise for enhancing cancer screening, refining diagnosis, and guiding personalized therapeutic strategies, thereby advancing the field of precision oncology.

