Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies01:22

Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies

752
The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...
752
Factors Influencing Heart Rate01:30

Factors Influencing Heart Rate

7.0K
The heart rate, or pulse rate, is a vital indicator of cardiovascular health. It reflects the number of times the heart beats per minute. Various physiological and environmental factors influence heart rate, increasing or decreasing cardiac output. Understanding these factors is crucial for assessing heart function and identifying potential health issues.
Let us explore the significant factors affecting heart rate, including age, body temperature, posture, acute pain, chemical influences,...
7.0K
Heart Failure IV: Classification and Diagnostic Evaluation01:30

Heart Failure IV: Classification and Diagnostic Evaluation

467
Heart failure can be classified in various ways, with the most common classifications based on physical activity limitations, disease progression, severity, and treatment strategies.The Functional Classification of Heart Failure divides patients into four categories based on physical activity limitation due to symptom burden.Class I: Patients in this class have cardiac disease but no physical activity limitations. Ordinary activities like walking, climbing stairs, or routine tasks do not cause...
467
Heart Failure III: Clinical Manifestations01:26

Heart Failure III: Clinical Manifestations

692
Heart failure (HF) manifests primarily as dyspnea, fatigue, and fluid retention, resulting in peripheral and pulmonary edema. Symptoms may vary depending on which ventricle is more affected, left or right.Left-Sided Heart FailureAlso known as left ventricular failure, this condition results from the left ventricle's inability to fill or eject sufficient blood into the systemic circulation. It leads to pulmonary congestion, which occurs when the left ventricle fails to eject blood effectively...
692
Atherosclerosis II: Clinical Manifestations and Diagnostic Tests01:27

Atherosclerosis II: Clinical Manifestations and Diagnostic Tests

616
Atherosclerosis is a progressive disorder that leads to the thickening and narrowing of arterial walls due to plaque buildup. This condition can cause various symptoms depending on the arteries affected:Coronary Artery Disease (CAD): This condition affects the coronary arteries and may lead to chest pain (angina), shortness of breath (dyspnea), heart attacks, and other heart disease symptoms.Cerebrovascular Disease: This affects blood flow to the brain, causing transient ischemic attacks (TIAs)...
616
Heart Failure II: Pathophysiology01:29

Heart Failure II: Pathophysiology

1.1K
Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
1.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Adverse event trajectories and treatment discontinuation in advanced Parkinson's disease treated with levodopa/carbidopa intestinal gel.

Parkinsonism & related disorders·2026
Same author

Atrial cardiomyopathy as a multidomain disease: longitudinal evidence for autonomic remodelling.

Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology·2026
Same author

Longitudinal Decline in Electrochemical Skin Conductance Reflects Disease Progression in Multiple System Atrophy.

European journal of neurology·2026
Same author

Development and Validation of the 3PDQ: A Self-Reported Questionnaire for Diagnosing Primary Pain in Parkinson's Disease.

Movement disorders : official journal of the Movement Disorder Society·2026
Same author

Correction: Heart rate variability provides prognostic value in multiple system atrophy.

Clinical autonomic research : official journal of the Clinical Autonomic Research Society·2026
Same author

Electrocardiographic assessment in obstructive sleep apnea: bridging pathophysiology and clinical practice.

Frontiers in physiology·2026
Same journal

Cardiovascular pharmacology of dopaminergic agents in humans: a review.

Clinical autonomic research : official journal of the Clinical Autonomic Research Society·2026
Same journal

Vagus nerve stimulation and pulmonary outcomes: a scoping review of preclinical and clinical evidence.

Clinical autonomic research : official journal of the Clinical Autonomic Research Society·2026
Same journal

Haemodynamics of (pre)syncope during carotid sinus massage: a beat-to-beat analysis of haemodynamic parameters during carotid sinus massage.

Clinical autonomic research : official journal of the Clinical Autonomic Research Society·2026
Same journal

Orthostatic hypotension and complaints: not a clear-cut relation.

Clinical autonomic research : official journal of the Clinical Autonomic Research Society·2026
Same journal

Co-occurrence of Chiari malformation type 1 and small fiber neuropathy in a family with a novel COL6A5 null variant.

Clinical autonomic research : official journal of the Clinical Autonomic Research Society·2026
Same journal

Postural tachycardia during active standing: diagnostic criteria in adolescents.

Clinical autonomic research : official journal of the Clinical Autonomic Research Society·2026
See all related articles

Related Experiment Video

Updated: Feb 25, 2026

Calculating Heart Rate Variability from ECG Data from Youth with Cerebral Palsy During Active Video Game Sessions
08:12

Calculating Heart Rate Variability from ECG Data from Youth with Cerebral Palsy During Active Video Game Sessions

Published on: June 5, 2019

20.6K

Heart rate variability provides prognostic value in multiple system atrophy.

Paulo Bastos1,2,3, Marc Kermorgant4,5,6, Margherita Fabbri7,8,4,5,6

  • 1Department of Clinical Pharmacology and Neurosciences, University of Toulouse 3, Hôpital Pierre Paul Riquet, Toulouse University Hospital, Place du Dr Baylac, 31059, Toulouse, France. pauloandrediasbastos01@gmail.com.

Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society
|February 23, 2026
PubMed
Summary
This summary is machine-generated.

Heart rate variability (HRV) offers insights into autonomic dysfunction in Multiple System Atrophy (MSA). HRV features correlate with disease severity and survival, complementing clinical scores for better prognostic understanding.

Keywords:
DysautonomiaHRVMSANeurodegeneration

More Related Videos

Autonomic Function Following Concussion in Youth Athletes: An Exploration of Heart Rate Variability Using 24-hour Recording Methodology
05:48

Autonomic Function Following Concussion in Youth Athletes: An Exploration of Heart Rate Variability Using 24-hour Recording Methodology

Published on: September 21, 2018

10.6K
Author Spotlight: Investigating HR-Dependent Cardiac Function in Mouse Models Through a Novel Atrial-Pacing Approach
07:49

Author Spotlight: Investigating HR-Dependent Cardiac Function in Mouse Models Through a Novel Atrial-Pacing Approach

Published on: July 21, 2023

2.0K

Related Experiment Videos

Last Updated: Feb 25, 2026

Calculating Heart Rate Variability from ECG Data from Youth with Cerebral Palsy During Active Video Game Sessions
08:12

Calculating Heart Rate Variability from ECG Data from Youth with Cerebral Palsy During Active Video Game Sessions

Published on: June 5, 2019

20.6K
Autonomic Function Following Concussion in Youth Athletes: An Exploration of Heart Rate Variability Using 24-hour Recording Methodology
05:48

Autonomic Function Following Concussion in Youth Athletes: An Exploration of Heart Rate Variability Using 24-hour Recording Methodology

Published on: September 21, 2018

10.6K
Author Spotlight: Investigating HR-Dependent Cardiac Function in Mouse Models Through a Novel Atrial-Pacing Approach
07:49

Author Spotlight: Investigating HR-Dependent Cardiac Function in Mouse Models Through a Novel Atrial-Pacing Approach

Published on: July 21, 2023

2.0K

Area of Science:

  • Neuroscience
  • Cardiology
  • Autonomic Nervous System Research

Background:

  • Multiple system atrophy (MSA) is a progressive neurodegenerative disorder with autonomic dysfunction, parkinsonism, and cerebellar impairment.
  • Disease progression in MSA is heterogeneous, making it challenging to correlate physiological markers with severity and survival.
  • Heart rate variability (HRV) noninvasively measures autonomic nervous system function, but its role in MSA requires further elucidation.

Purpose of the Study:

  • To investigate the association between heart rate variability (HRV) features and clinical severity in Multiple System Atrophy (MSA).
  • To examine the relationship between HRV metrics and survival outcomes in MSA patients.
  • To explore whether HRV provides complementary information to existing clinical scales for predicting MSA progression.

Main Methods:

  • The study included 214 patients diagnosed with MSA.
  • Regression models were employed to analyze the association between HRV features and disease severity (Unified MSA Rating Scale - UMSARS).
  • Survival analyses and mediation analyses were conducted to assess HRV's contribution to risk stratification and its relationship with UMSARS and survival.

Main Results:

  • HRV features showed a negative association with disease severity, indicating progressive autonomic dysfunction in MSA.
  • Combined HRV features demonstrated a stronger relationship with UMSARS than individual features.
  • Models incorporating HRV showed comparable associations with survival time as UMSARS, with improved accuracy when both were combined.
  • Mediation analyses indicated that HRV captures survival-related physiological information not fully represented by clinical severity scores.

Conclusions:

  • HRV features are significantly associated with both disease severity and survival in MSA patients.
  • HRV provides valuable physiological information that complements established clinical scales in MSA.
  • These findings support HRV as a potential exploratory tool for autonomic dysfunction in MSA and identify candidate features for future research.