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Association between postzoster neuralgia and tinnitus: A retrospective population-based cohort study
Cha Dong Yeo1,2, Haeng-Jin Lee2,3, Sein Lee1,2
1Department of Otorhinolaryngology-Head and Neck Surgery, College of Medicine, Jeonbuk National University, Jeonju, Republic of Korea.
Medicine
|February 24, 2026
Summary
Postzoster neuralgia (PZN) is linked to a higher incidence of tinnitus, especially in older adults and females. Comorbidities like anxiety and hearing loss further increase tinnitus risk in PZN patients.
Area of Science:
- Neurology
- Otolaryngology
- Epidemiology
Background:
- Tinnitus, the perception of sound without external stimuli, lacks extensive research regarding its association with postzoster neuralgia (PZN) in large-scale, real-world data.
- Postzoster neuralgia is a chronic pain condition that can significantly impact quality of life.
Purpose of the Study:
- To investigate the potential correlation between tinnitus and postzoster neuralgia (PZN).
- To identify risk factors for developing tinnitus in individuals with PZN.
Main Methods:
- Utilized the National Health Insurance Service - National Sample Cohort database, a nationwide population-based dataset.
- Selected a PZN cohort (3417 individuals) and a matched non-PZN control group.
- Propensity score matching was employed to control for confounding variables.
Main Results:
- The PZN group exhibited a 1.35 times higher incidence of tinnitus compared to the control group (HR 1.35, 95% CI: 1.18-1.55).
- Increased tinnitus risk was observed in middle-aged (HR 1.99) and older adults (HR 2.37), and females.
- Comorbidities such as anxiety (HR 1.46), hearing loss (HR 3.34), and sleep disorders (HR 1.48) were associated with higher tinnitus risk.
Conclusions:
- Postzoster neuralgia is an independent risk factor for developing tinnitus.
- Older age, female sex, anxiety, hearing loss, and sleep disorders are significant risk factors for tinnitus in the PZN population.
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