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Optimized Analysis of In Vivo and In Vitro Hepatic Steatosis
Published on: March 11, 2017
Evolution patterns of posttranslational modifications in metabolic dysfunction-associated fatty liver disease: a
Dian Qiang Yang1, Shun Mei Huang2,3, Sui Sui Luo2,3
1Zhejiang Key Laboratory of Geriatrics and Geriatrics Institute of Zhejiang Province, Affiliated Zhejiang Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, People's Republic of China.
Posttranslational modifications (PTMs) are key in metabolic dysfunction-associated fatty liver disease (MAFLD) pathogenesis. This bibliometric analysis maps global research trends, identifying emerging themes like ubiquitination and acetylation to guide future MAFLD studies.
Area of Science:
- Hepatology and Molecular Biology
- Biochemistry and Metabolism
Background:
- Metabolic dysfunction-associated fatty liver disease (MAFLD) is a prevalent chronic liver condition and a significant risk factor for advanced liver disease.
- Posttranslational modifications (PTMs) play a critical role in regulating lipid metabolism, inflammation, and fibrosis, thereby influencing MAFLD pathogenesis.
Purpose of the Study:
- To systematically analyze research trends and identify knowledge gaps in the field of PTMs in MAFLD.
- To provide a data-driven overview of the global research landscape concerning PTMs and MAFLD.
Main Methods:
- Bibliometric analysis of publications from 2005-2024 retrieved from the Web of Science Core Collection.
- Quantitative and qualitative analysis using CiteSpace, VOSviewer, Bibliometrix in R, and large language models.
- Identification of publication output, citation counts, key institutions, influential authors, and leading journals.
Main Results:
- A total of 2401 publications were analyzed, showing a 20.76% annual growth rate.
- China led in publication output, while the United States had the highest citation count.
- Emerging research themes include "molecular docking", "ubiquitination", "N6-methyladenosine", "acetylation", "methylation", and "metabolism".
Conclusions:
- This study maps the global research landscape of PTMs in MAFLD, highlighting key trends and collaborations.
- Identified emerging research frontiers, such as specific PTMs and their roles in MAFLD pathogenesis, provide a foundation for future investigations.
- Large language models offer insights into the complex mechanisms underlying MAFLD, paving the way for advanced understanding and potential therapeutic strategies.
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