Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Insufficient Sleep and Sleep Deprivation01:13

Insufficient Sleep and Sleep Deprivation

978
Insufficient sleep refers to not getting the recommended amount of sleep for optimal functioning, even if it's just slightly less than needed. Sleep insufficiency may occur due to lifestyle choices, such as staying up late for social events or work, resulting in routinely getting less sleep than required. For example, consistently sleeping 6 hours when the body needs 7-9 hours can lead to cumulative effects on health and well-being.
Sleep deprivation is a more severe form of sleep loss...
978
Understanding Sleep01:11

Understanding Sleep

1.7K
Sleep, an essential biological state, involves significant reductions in physical activity, sensory awareness, and interaction with the environment. This complex physiological process is primarily regulated by specific brain regions, notably the hypothalamus and pons, which govern the sleep-wake cycle or circadian rhythm.
The circadian rhythm, a nearly 24-hour cycle, is deeply influenced by environmental light cues. Light exposure directly affects the hypothalamus, which in turn regulates...
1.7K
Sleep-Wake Cycles01:24

Sleep-Wake Cycles

3.1K
Sleep is an essential physiological process vital to maintaining overall well-being. The reticular activating system (RAS), a network of neurons in the brainstem, regulates wakefulness and sleep. While it may seem passive, sleep consists of distinct cycles, each with its unique characteristics and functions. Two key sleep phases are non-rapid eye movement (NREM) and  rapid eye movement (REM).
NREM Sleep
NREM sleep comprises four progressive stages that seamlessly merge:
3.1K
Factors Affecting the Risk of Infection01:26

Factors Affecting the Risk of Infection

14.1K
The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
14.1K
Immunodeficiency Diseases01:25

Immunodeficiency Diseases

2.6K
Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency...
2.6K
Substance Use Disorders Affecting Sleep01:24

Substance Use Disorders Affecting Sleep

471
Substance use disorders involve a pattern of using drugs more extensively than intended and continuing use despite harmful consequences. This includes legal substances like alcohol and nicotine, as well as illegal drugs. These disorders often involve both physical and psychological dependence, reflecting compulsive use of substances that significantly alter thoughts, feelings, and behaviors, contributing to a major public health issue.
Understanding the concepts of physical dependence,...
471

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Hydrogen Atom Transfer Chemistry for Chemical Upcycling of Commodity Polymers.

Polymer science & technology (Washington, D.C.)·2026
Same author

Dual-Surfactant-Directed Mesoporous Metal-Alkyl-Thiol Frameworks for Enzyme-Au Nanoparticle-Coupled SERS Biosensing.

Small methods·2026
Same author

Fetal health state detection method based on parameters efficient ensembling of deep learning.

Frontiers in public health·2026
Same author

Crystallization-driven co-self-seeding strategy toward controlled preparation of heterojunction nanofibers.

Chemical communications (Cambridge, England)·2026
Same author

Identification of a Germline <i>XAF1</i> Mutation in Patients With Gastrointestinal Cancers.

Human mutation·2026
Same author

A real-world multicenter study of first-line zanubrutinib-based therapy for diffuse large B-cell lymphoma.

Leukemia & lymphoma·2026

Related Experiment Video

Updated: Feb 25, 2026

Establishing a Device for Sleep Deprivation in Mice
05:05

Establishing a Device for Sleep Deprivation in Mice

Published on: September 22, 2023

2.6K

Sleep deprivation silently undermines immunity.

Qiao Zhou1, Chun Feng1, Shuang Li1

  • 1Pain and Sleep Treatment Center, Wuhan Children's Hospital (Wuhan Maternal and Child Healthcare Hospital), Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

International Journal of Surgery (London, England)
|February 24, 2026
PubMed
Summary

Sleep deprivation (SD) significantly harms immune function and increases disease risk. This review explores SD

Keywords:
immune dysfunctionimmune parametersimmune-related diseasessleep deprivation

More Related Videos

Chronic Sleep Deprivation in Mouse Pups by Means of Gentle Handling
03:46

Chronic Sleep Deprivation in Mouse Pups by Means of Gentle Handling

Published on: October 11, 2018

11.1K
A Chronic Sleep Fragmentation Model using Vibrating Orbital Rotor to Induce Cognitive Deficit and Anxiety-Like Behavior in Young Wild-Type Mice
06:23

A Chronic Sleep Fragmentation Model using Vibrating Orbital Rotor to Induce Cognitive Deficit and Anxiety-Like Behavior in Young Wild-Type Mice

Published on: September 22, 2020

6.1K

Related Experiment Videos

Last Updated: Feb 25, 2026

Establishing a Device for Sleep Deprivation in Mice
05:05

Establishing a Device for Sleep Deprivation in Mice

Published on: September 22, 2023

2.6K
Chronic Sleep Deprivation in Mouse Pups by Means of Gentle Handling
03:46

Chronic Sleep Deprivation in Mouse Pups by Means of Gentle Handling

Published on: October 11, 2018

11.1K
A Chronic Sleep Fragmentation Model using Vibrating Orbital Rotor to Induce Cognitive Deficit and Anxiety-Like Behavior in Young Wild-Type Mice
06:23

A Chronic Sleep Fragmentation Model using Vibrating Orbital Rotor to Induce Cognitive Deficit and Anxiety-Like Behavior in Young Wild-Type Mice

Published on: September 22, 2020

6.1K

Area of Science:

  • Immunology
  • Sleep Science
  • Public Health

Background:

  • Sleep is vital for health, immune function, and cognitive performance.
  • Societal changes have led to widespread sleep deprivation (SD), increasing sleep disorders.
  • SD negatively impacts immune responses, promotes inflammation, and elevates disease susceptibility.

Purpose of the Study:

  • To investigate the intricate relationship between sleep deprivation and immune function.
  • To elucidate the underlying mechanisms connecting SD to immune system alterations.
  • To inform future research and therapeutic interventions for SD-related immune dysfunction.

Main Methods:

  • Literature review of existing studies on sleep deprivation and immunity.
  • Analysis of immunological markers and inflammatory pathways affected by SD.
  • Synthesis of current understanding of SD's impact on immune health.

Main Results:

  • Sleep deprivation demonstrably impairs immune responses.
  • SD is linked to increased systemic inflammation and vulnerability to infections.
  • Specific immune cell functions and cytokine profiles are altered by SD.

Conclusions:

  • Sleep deprivation poses a significant threat to immune health.
  • Understanding the mechanisms is crucial for developing interventions.
  • Further research is needed to fully address the public health implications of SD.