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Comparative Efficacy and Safety of Different Assisted-fat Transplantation Methods: A Network Meta-analysis of
Yifei Li1, Qianwen Lv2, Yunpeng Gu2
1Department of General Plastic Surgery, Plastic Surgery Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China.
Aesthetic Surgery Journal
|February 24, 2026
Summary
Autologous fat grafting outcomes improved with supplements like stem cells, platelet-rich plasma (PRP), and stromal vascular fraction (SVF). Stem cell-enriched grafts showed the most promise for fat volume retention and effectiveness in plastic and reconstructive surgery.
Area of Science:
- Plastic and Reconstructive Surgery
- Regenerative Medicine
- Biomaterials Science
Background:
- Autologous fat grafting is a common technique for volume augmentation in plastic and reconstructive surgery.
- Enhancing fat graft survival and volume retention remains a clinical challenge.
- Various supplements are being investigated to improve fat graft outcomes.
Purpose of the Study:
- To compare the efficacy of different supplements used with autologous fat grafting.
- To evaluate outcomes such as volume retention, complication rates, and patient satisfaction.
- To identify the most effective assisted fat grafting techniques.
Main Methods:
- A systematic review and meta-analysis of randomized controlled trials.
- Searched databases for studies on fat transplantation with supplements like PRP, PRF, SVF, mesenchymal stem cells, and growth factors.
- Assessed primary outcomes of volume retention and secondary outcomes including complications and effectiveness.
Main Results:
- Significant improvements in fat volume retention were observed with Stem Cells, Platelet-Rich Plasma (PRP), and Stromal Vascular Fraction (SVF) compared to controls.
- Stem cell-enriched grafts showed the highest potential for effectiveness.
- The Cellular Growth Factor (CGF) procedure had the fewest complications, while SVF, PRP, and Platelet-Rich Fibrin (PRF) showed superior effectiveness.
Conclusions:
- Assisted fat grafting methods, particularly those involving stem cells, PRP, and SVF, demonstrate improved efficacy and safety.
- Stem cell-based products show considerable clinical potential for enhancing fat graft outcomes.
- Therapeutic choices should be individualized based on clinical setting and patient needs.
