Related Experiment Video
Updated: Feb 25, 2026

Assessing Bacterial Invasion of Cardiac Cells in Culture and Heart Colonization in Infected Mice Using Listeria monocytogenes
Published on: May 27, 2015
Lomentospora prolificans infective endocarditis and cerebral mycotic aneurysm
Robert Hand1, J Owen Robinson1,2,3, Paul Cannell4
1Infectious Diseases Department, Fiona Stanley Hospital, 11 Robin Warren Ave, Murdoch, Perth, 6150, Australia.
Abstract:
Disseminated Lomentospora prolificans infection typically occurs in immunocompromised hosts and is almost universally fatal. We describe a case of L. prolificans native valve infective endocarditis with cerebral mycotic aneurysm after recovery from allogeneic stem cell transplant. The case is notable for minimal immunosuppression at diagnosis, and pathological evidence of infection at sites which looked normal at surgery or by imaging. With early surgery and olorofim the patient survived to 76 days after diagnosis.
Insights
Disseminated Lomentospora prolificans infection is rare in immunocompromised patients. This case highlights a successful outcome with early surgery and olorofim treatment for Lomentospora prolificans endocarditis and aneurysm.
Area of Science:
- Mycology
- Infectious Diseases
- Transplant Surgery
Background:
- Disseminated Lomentospora prolificans infection is a rare and often fatal fungal infection.
- It predominantly affects immunocompromised individuals, posing significant treatment challenges.
Related Concept Videos
Endocarditis II: Clinical Features of Infective Endocarditis
Endocarditis I: Introduction
Fungal Group Zygomycota
Myocarditis I: Introduction
Endocarditis III: Medical Management
Aneurysm II: Clinical Manifestations and Diagnostic Studies

