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Updated: Feb 25, 2026

Cytotoxic Efficacy of Photodynamic Therapy in Osteosarcoma Cells In Vitro
08:04

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Published on: March 18, 2014

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PCMTD1-127aa suppresses osteosarcoma progression by competitively binding to USP10 to promote c-MYC degradation

Anan Li1,2,3, Shijiang Wang1,2,3, Fan Li4

  • 1Department of Orthopedic Surgery, the First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang 330006, P.R. China.

Iscience
|February 24, 2026
PubMed

Insights

A newly identified protein, PCMTD1-127aa, is significantly underexpressed in osteosarcoma (OS) and linked to poor prognosis. Its restoration inhibits OS cell growth and metastasis, offering a potential therapeutic target.

Area of Science:

  • Oncology
  • Molecular Biology
  • Biochemistry

Background:

  • Osteosarcoma (OS) is a malignant bone tumor with poor prognosis and limited therapeutic options.
  • Metastasis and uncontrolled proliferation are hallmarks of OS, driving poor patient outcomes.

Purpose of the Study:

  • To investigate the role of a novel protein, PCMTD1-127aa, encoded by circPCMTD1 in osteosarcoma.
  • To elucidate the molecular mechanisms underlying PCMTD1-127aa's function in OS progression.

Main Methods:

  • Analysis of PCMTD1-127aa expression in OS tissues and correlation with clinical data.
  • Functional studies involving overexpression of PCMTD1-127aa in OS cells to assess proliferation, invasion, and glycolysis.
  • Mechanistic investigations into the interaction between PCMTD1-127aa, USP10, and c-MYC.

Main Results:

  • PCMTD1-127aa expression was significantly lower in OS tissues and associated with poor prognosis.
  • Overexpression of PCMTD1-127aa suppressed OS cell proliferation, invasion, and glycolysis.
  • PCMTD1-127aa competitively binds USP10, inhibiting c-MYC deubiquitination and promoting c-MYC degradation.

Conclusions:

  • The PCMTD1-127aa/USP10/c-MYC signaling axis represents a potential therapeutic target for osteosarcoma.
  • Restoring PCMTD1-127aa function may offer a novel strategy to combat OS progression and metastasis.
Keywords:
Biological sciencesCancer

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