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Advances in the study of nucleolar small RNAs in colorectal cancer

Ziwen Yuan1, Yafang Chen1, Sicong Liu1

  • 1Department of Laboratory Medicine, Affiliated Hospital of Nantong University, Medical School of Nantong University, Nantong, Jiangsu, China.

Iscience
|February 24, 2026
PubMed

Insights

Small nucleolar RNAs (snoRNAs) are crucial in colorectal cancer (CRC) development. These molecules show promise as biomarkers for early detection and improved cancer management through liquid biopsies.

Area of Science:

  • Molecular biology
  • Oncology
  • Biomarker discovery

Background:

  • Colorectal cancer (CRC) presents a significant global health burden, necessitating advanced diagnostic methods.
  • Emerging research highlights the involvement of small nucleolar RNAs (snoRNAs) in the pathogenesis of CRC.

Purpose of the Study:

  • To review the molecular and functional aspects of snoRNAs in CRC.
  • To explore the role of snoRNAs in colorectal carcinogenesis.
  • To assess the potential of snoRNAs as liquid biopsy biomarkers for clinical application.

Main Methods:

  • Literature review and synthesis of current research on snoRNAs and CRC.
  • Analysis of molecular characteristics and physiological functions of snoRNAs.
  • Discussion of snoRNA mechanisms in colorectal cancer development.

Main Results:

  • snoRNAs exhibit diverse molecular characteristics and physiological roles relevant to cancer.
  • Specific snoRNAs are implicated in the mechanisms driving colorectal carcinogenesis.
  • snoRNAs demonstrate potential as non-invasive biomarkers in liquid biopsies.

Conclusions:

  • snoRNAs are integral to colorectal cancer progression and represent promising targets for diagnostics.
  • Further research into snoRNAs could lead to novel clinical strategies for CRC detection and management.
  • The translation of snoRNA-based liquid biopsies holds significant prospects for improving patient outcomes in CRC.
Keywords:
CancerMolecular biology

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