Pathogenesis of adjuvant-induced destructive periodontitis in marmosets

The histologic reaction of the marmoset periodontium to a single intragingival injection of CFA was followed sequentially over a 2-week period. The earliest lesions were nonspecific and similar to IFA-induced responses. After 4 days the CFA-produced lesions were markedly destructive of periodontal bone, whereas the IFA reaction was not, indicating that the alveolar bone destruction that stemmed form the CFA injection may have been immunologically mediated.