Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Pharmacokinetics in Pediatric Patients: Drug Excretion01:26

Pharmacokinetics in Pediatric Patients: Drug Excretion

329
In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...
329
Drug Dosing: Infants and Children01:29

Drug Dosing: Infants and Children

388
Pediatric patient dosages diverge from adults due to disparities in body surface area, total body water, and extracellular fluid per kilogram of body weight. The dosing regimen considers the variations in pharmacokinetics and pharmacology across distinct age groups, encompassing preterm newborns, infants, young children, older children, and adolescents. Calculation of pediatric patient doses is predicated on determining body surface area, which exhibits a superior correlation with the child's...
388
Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption01:23

Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption

375
Understanding the physiological differences in the pediatric population is crucial for effective pharmacotherapy. Neonates, infants, and children exhibit significant variations in gastric pH, gastric emptying time, intestinal transit time, and biliary function. These variations profoundly affect oral drug absorption, necessitating a nuanced approach to pediatric dosing.Neonates present with a unique physiological profile, having a gastric pH greater than 4 and faster and more irregular gastric...
375
Pharmacokinetics in Pediatric Patients: Drug Metabolism01:24

Pharmacokinetics in Pediatric Patients: Drug Metabolism

286
In pediatric care, understanding the nuances of hepatic drug metabolism is crucial, as it significantly differs from that of adults. This divergence is primarily due to the developmental stage of drug-metabolizing enzymes, which affects how medications are processed in the body. In neonates, for instance, the activity of Phase I enzymes—critical for the initial breakdown of drugs—is markedly reduced, functioning at just 20–40% of the levels seen in adults. This reduction poses...
286
Pharmacokinetics in Pediatric Patients: Drug Distribution01:17

Pharmacokinetics in Pediatric Patients: Drug Distribution

359
Drug distribution in the pediatric population exhibits unique challenges and considerations due to the physiological differences between children, particularly neonates and infants, and adults. A crucial aspect of pediatric pharmacology is understanding how these differences impact the pharmacokinetics of various drugs, necessitating age-specific dosing strategies to ensure efficacy and safety.Neonates and infants have a higher total body water content, ~75%–90% of their body weight,...
359
Pharmaceutical Poisoning: Potential Scenarios01:26

Pharmaceutical Poisoning: Potential Scenarios

37
Pharmaceutical poisoning can occur through various channels, impacting an estimated 2 million hospitalized patients in the U.S. annually with serious adverse drug responses. These scenarios encompass both therapeutic uses, such as drug toxicity, where even standard dosages can lead to severe central nervous system depression, and non-therapeutic exposures, including accidental ingestion by children, and environmental and occupational exposures.Unintentional poisonings often involve exploratory...
37

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Factors associated with postpartum depression in mothers of the kangaroo mother care program in Southern Colombia: a cross-sectional study.

Scientific reports·2026
See all related articles

Related Experiment Video

Updated: Feb 25, 2026

A Novel Approach for the Administration of Medications and Fluids in Emergency Scenarios and Settings
06:59

A Novel Approach for the Administration of Medications and Fluids in Emergency Scenarios and Settings

Published on: November 9, 2016

31.4K

Objective Structured Clinical Examination for pediatric medication administration.

Mery Luz Valderrama-Sanabria1, Gisella Bonilla-Santos2, Daniela Muñoz-Duitama3

  • 1Nurse, Professor, Universidad de los Llanos, Villavicencio, Colombia E-mail: mvalderrama@unillanos.edu.co Universidad de los Llanos Villavicencio Colombia mvalderrama@unillanos.edu.co.

Revista Cuidarte
|February 24, 2026
PubMed
Summary
This summary is machine-generated.

The objective structured clinical examination (OSCE) is a valid tool for assessing nursing students' pediatric medication administration skills. This psychometric evaluation confirms its reliability for educational and professional practice.

Keywords:
Drug Dosage CalculationsNursingPediatricsReproducibility of Results

More Related Videos

Universal Screening for Prevention of Reading, Writing, and Math Disabilities in Spanish
14:43

Universal Screening for Prevention of Reading, Writing, and Math Disabilities in Spanish

Published on: July 18, 2020

8.6K
Assessment and Evaluation of the High Risk Neonate: The NICU Network Neurobehavioral Scale
19:15

Assessment and Evaluation of the High Risk Neonate: The NICU Network Neurobehavioral Scale

Published on: August 25, 2014

88.2K

Related Experiment Videos

Last Updated: Feb 25, 2026

A Novel Approach for the Administration of Medications and Fluids in Emergency Scenarios and Settings
06:59

A Novel Approach for the Administration of Medications and Fluids in Emergency Scenarios and Settings

Published on: November 9, 2016

31.4K
Universal Screening for Prevention of Reading, Writing, and Math Disabilities in Spanish
14:43

Universal Screening for Prevention of Reading, Writing, and Math Disabilities in Spanish

Published on: July 18, 2020

8.6K
Assessment and Evaluation of the High Risk Neonate: The NICU Network Neurobehavioral Scale
19:15

Assessment and Evaluation of the High Risk Neonate: The NICU Network Neurobehavioral Scale

Published on: August 25, 2014

88.2K

Area of Science:

  • Nursing Education
  • Clinical Competency Assessment
  • Pediatric Nursing

Background:

  • Systematic evaluation of nursing competencies is crucial for tracking professional development.
  • Clinical simulation and objective structured clinical examinations (OSCEs) are vital tools for nursing education.
  • Assessing competence in pediatric medication administration is a key area for nursing practice.

Purpose of the Study:

  • To determine the construct validity of the objective structured clinical examination (OSCE).
  • To assess nursing professionals' competence in pediatric medication administration.
  • To validate an instrument for objective structured clinical examination in pediatric medication administration.

Main Methods:

  • An observational, psychometric, and prospective study design was employed.
  • The study focused on the validity and reliability of a specific OSCE instrument.
  • Statistical analyses included Bartlett's test of sphericity and Kaiser-Meyer-Olkin (KMO).

Main Results:

  • The final OSCE instrument comprised 15 items.
  • Bartlett's test (χ2 =145.887, p < 0.001) and KMO (0.703) indicated suitability for factor analysis.
  • Cronbach's alpha for the instrument was 0.798, demonstrating good internal consistency.

Conclusions:

  • The OSCE instrument demonstrated established validity for assessing pediatric medication administration competence.
  • The instrument is moderately acceptable for use in nursing education and practice.
  • Utilizing this OSCE supports both the learning and evaluation of clinical skills for health science students.