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Related Concept Videos

Transdermal Drug Delivery Systems01:18

Transdermal Drug Delivery Systems

233
Transdermal drug delivery systems (TDDS) enable the controlled release of drugs across the skin into systemic circulation. They are particularly advantageous for drugs with short half-lives or narrow therapeutic indices, as they maintain consistent plasma concentrations and reduce the risk of subtherapeutic or toxic levels.TDDS are categorized into monolithic, reservoir, and mixed systems. Monolithic systems embed the drug in a polymer matrix, where diffusion governs release. Reservoir systems...
233

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Related Experiment Video

Updated: May 6, 2026

Autonomous and Rechargeable Microneurostimulator Endoscopically Implantable into the Submucosa
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Flexible biodegradable wireless battery-free integrated theranostic adhesive patch.

Shuaiyin Liu1,2, Jian Huang3, Junlin Chen1

  • 1Key Laboratory of Biomechanics and Mechanobiology (Beihang University), Ministry of Education, Key Laboratory of Innovation and Transformation of Advanced Medical Devices, Ministry of Industry and Information Technology, National Medical Innovation Platform for Industry-Education Integration in Advanced Medical Devices (Interdiscipline of Medicine and Engineering), School of Biological Science and Medical Engineering, Beihang University, Beijing, 100083, China.

Bioactive Materials
|February 24, 2026
PubMed
Summary

This study introduces a biodegradable theranostic patch for wireless, real-time diagnosis and treatment. The integrated theranostic adhesive patch (ITAP) offers precise drug delivery and monitoring on wet tissues.

Keywords:
BioadhesionBioresorbableTheranosticsWireless controlWireless sensing

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Area of Science:

  • Biomedical Engineering
  • Materials Science
  • Nanotechnology

Background:

  • Current drug delivery and diagnostic methods struggle with precision medicine requirements.
  • Existing theranostic systems face limitations like wired control, non-degradable materials, and poor wet-tissue adhesion.
  • There is a need for advanced, minimally invasive theranostic solutions for dynamic biological environments.

Purpose of the Study:

  • To develop an integrated theranostic adhesive patch (ITAP) for wireless, biodegradable, and bioadhesive diagnosis and therapy.
  • To demonstrate the ITAP's capability for real-time physiological monitoring and on-demand drug delivery on wet tissues.
  • To evaluate the safety, efficacy, and transient nature of the developed theranostic platform.

Main Methods:

  • Fabrication of an ITAP utilizing a biocompatible hydrogel for adhesion and resonant mechanical sensing for motion monitoring.
  • Integration of magnetically activated electrochemical corrosion of magnesium (Mg) valves for controlled drug release.
  • Development of thickness-graded Mg valves and distance-dependent magnetic actuation for programmable, sequential drug release.
  • In vivo studies in an asthmatic rat model for functional validation, including respiratory monitoring and triggered drug delivery.
  • In vitro degradation and in vivo biocompatibility assessments.

Main Results:

  • The ITAP demonstrated strong adhesion to moist tissues and sensitive detection of physiological motion.
  • Precise, on-demand drug release was achieved via magnetic stimulation of Mg valves, enabling programmable and selective delivery.
  • In vivo studies showed successful wireless respiratory monitoring and effective triggered bronchodilator delivery in an asthmatic rat model.
  • Degradation and biocompatibility tests confirmed the transient and safe nature of the ITAP components, eliminating the need for retrieval.

Conclusions:

  • The developed bioresorbable ITAP provides a practical platform for wireless, tissue-conformal diagnosis and therapy.
  • This technology enables minimally invasive and personalized interventions on dynamic wet tissue surfaces.
  • The ITAP overcomes limitations of conventional systems, paving the way for advanced theranostic applications.