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Altered anterior segment biometrics in cataract patients with retinitis pigmentosa: a propensity-matched analysis
Yonglin Chen1, Zhiheng Lian1, Yongguo Xiang1
1The First Affiliated Hospital of Chongqing Medical University, Chongqing Key Laboratory of Prevention and Treatment on Major Blinding Diseases, Chongqing Eye Institute, Chongqing Branch (Municipality Division) of National Clinical Research Center for Ocul, Chong Qing, China.
Purpose:
To explore the spatial structure of the anterior segment biometrics in cataract patients with retinitis pigmentosa (RP).
Methods:
This is a retrospective study. We conducted a propensity score matching analysis (1:3) on anterior segment data of RP patients and normal cataract patients who underwent cataract surgery from August 2023 to February 2025. Baseline variables (age, gender, axial length, and Pentacam Nucleus Staging (PNS) score) were balanced to compare the differences in anterior segment biometric measurements between the two groups.
Results:
We analyzed the anterior segment data of 37 cataract patients with RP and 102 simple cataract patients. The RP group exhibited a thicker lens (p < 0.001), a more anterior lens position (p = 0.003), a shallower anterior chamber depth (p < 0.001), and greater corneal astigmatism (p < 0.001). The shallower anterior chamber depth showed a positive correlation with a more anterior lens position (r = 0.84, p < 0.001) and the relative lens position (r = 0.59, p < 0.001).
Discussions:
RP patients exhibit a thicker lens, a more anteriorly positioned lens, shallower anterior chamber depth, and greater corneal astigmatism. These changes can be explained by zonular weakness. Decision-making surrounding intraocular lens selection in eyes with RP, cataract, and zonular compromise may be enhanced through proper identification of preoperative biometric irregularities in the anterior segment.
