Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Diabetes Mellitus: Overview and Type I Subtype

Diabetes Mellitus: Overview and Type I Subtype

Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

In Vivo Quantification of Bruch's Membrane Changes in Angioid Streaks and Neovascular AMD Using Multimodal Imaging.

American journal of ophthalmology·2026

Same author

Association between angiogenic features and responsiveness to faricimab in treatment-naïve neovascular age-related macular degeneration with OCT angiography.

Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie·2026

Same author

Nationwide Multicenter Survey of Severe Complications of Strabismus Surgery in Japan: Japanese Strabismus Surgery Study.

Ophthalmology science·2026

Same author

Correction: Uptrend in esotropia incidence in the era of excessive smartphone use: A nationwide population-based cohort study in Japan, 2014-2019.

PLOS digital health·2026

Same author

Qualitative and Quantitative Assessment of Restored Capillary Perfusion on OCT Angiography in Diabetic Macular Ischemia.

Translational vision science & technology·2026

Same author

The JFC Method: A Proof-of-Concept Report on the Surgical Technique and Initial Feasibility of a Novel Flanged-Cord Temporary Occlusion for Non-Valved Glaucoma Drainage Devices.

Clinical ophthalmology (Auckland, N.Z.)·2026

Search research articles

Related Experiment Video

Updated: Feb 25, 2026

Evidence-based Knowledge Synthesis and Hypothesis Validation: Navigating Biomedical Knowledge Bases via Explainable AI and Agentic Systems

Evidence-based Knowledge Synthesis and Hypothesis Validation: Navigating Biomedical Knowledge Bases via Explainable AI and Agentic Systems

Published on: June 13, 2025

Exploration of Morphological Characteristics in Diabetic Macular Ischemia Utilizing a Large Language Model-Assisted

Miyo Yoshida¹, Tomoaki Murakami¹, Kenji Ishihara¹

¹Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan.

Ophthalmology Science

|February 24, 2026

Summary

This study used AI to build a knowledge graph from DMI literature, identifying novel concepts like Disorganization of MIddle retinal Layers (DMIL) and degenerative DMI. These findings were validated in patient data, showing significant impacts on visual acuity.

Keywords:

Diabetic macular edema Diabetic macular ischemia OCT OCT angiography Visual acuity

More Related Videos

A Knowledge Graph Approach to Elucidate the Role of Organellar Pathways in Disease via Biomedical Reports

A Knowledge Graph Approach to Elucidate the Role of Organellar Pathways in Disease via Biomedical Reports

Published on: October 13, 2023

Author Spotlight: Overcoming Anti-VEGF Resistance Through Advanced Vascular Morphology Assessment in Choroidal Neovascularization

Author Spotlight: Overcoming Anti-VEGF Resistance Through Advanced Vascular Morphology Assessment in Choroidal Neovascularization

Published on: August 11, 2023

Related Experiment Videos

Last Updated: Feb 25, 2026

Evidence-based Knowledge Synthesis and Hypothesis Validation: Navigating Biomedical Knowledge Bases via Explainable AI and Agentic Systems

Evidence-based Knowledge Synthesis and Hypothesis Validation: Navigating Biomedical Knowledge Bases via Explainable AI and Agentic Systems

Published on: June 13, 2025

A Knowledge Graph Approach to Elucidate the Role of Organellar Pathways in Disease via Biomedical Reports

A Knowledge Graph Approach to Elucidate the Role of Organellar Pathways in Disease via Biomedical Reports

Published on: October 13, 2023

Author Spotlight: Overcoming Anti-VEGF Resistance Through Advanced Vascular Morphology Assessment in Choroidal Neovascularization

Author Spotlight: Overcoming Anti-VEGF Resistance Through Advanced Vascular Morphology Assessment in Choroidal Neovascularization

Published on: August 11, 2023

Area of Science:

Ophthalmology
Medical Informatics
Artificial Intelligence

Background:

Diabetic macular ischemia (DMI) poses a significant threat to vision.
Current understanding of DMI terminologies may be incomplete.
Novel approaches are needed to synthesize complex clinical information.

Purpose of the Study:

To explore novel clinical terminologies in DMI using a large language model-assisted knowledge graph (KG).
To construct a KG from published literature on DMI.
To validate the KG-derived findings using clinical data.

Main Methods:

A systematic literature review identified 66 articles on DMI.
Generative pre-trained transformer 4 processed texts into entity-relation triplets.
Neo4j was used to assemble a KG, with community detection identifying novel concepts: Disorganization of MIddle retinal Layers (DMIL) and degenerative DMI.

Main Results:

The KG contained 2408 entities and 8133 relations, revealing structured relationships in DMI.
Novel terminologies DMIL and degenerative DMI were identified.
DMIL was associated with significantly worse visual acuity (P < 0.001).
Degenerative DMI correlated with capillary nonperfusion and visual acuity reduction (P < 0.001).

Conclusions:

Large language model-assisted KG construction objectively synthesizes clinical literature.
This approach facilitates the exploration of known and unknown clinical characteristics in DMI.
Novel terminologies like DMIL and degenerative DMI offer new insights into DMI pathophysiology and clinical impact.