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Updated: Feb 26, 2026

Single-cell Analysis of Immunophenotype and Cytokine Production in Peripheral Whole Blood via Mass Cytometry

Single-cell Analysis of Immunophenotype and Cytokine Production in Peripheral Whole Blood via Mass Cytometry

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Multi-Omic Profiling Reveals Immune Cell Priming Signature Linked to Lupus Prognosis.

Michael A Smith¹, Dominic Sinibaldi², Saifur Rahman¹

¹BioPharmaceuticals R&D, AstraZeneca, Gaithersburg, Maryland.

Arthritis & Rheumatology (Hoboken, N.J.)

|February 24, 2026

Summary

Researchers identified novel protein signatures in systemic lupus erythematosus (SLE) patients, revealing distinct organ pathologies and predicting future organ damage. This discovery offers new therapeutic targets for this complex autoimmune disease.

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Last Updated: Feb 26, 2026

Single-cell Analysis of Immunophenotype and Cytokine Production in Peripheral Whole Blood via Mass Cytometry

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Published on: June 26, 2018

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Screening for Functional Non-coding Genetic Variants Using Electrophoretic Mobility Shift Assay EMSA and DNA-affinity Precipitation Assay DAPA

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Published on: August 21, 2016

Area of Science:

Immunology
Genomics
Proteomics

Background:

Systemic lupus erythematosus (SLE) is a complex autoimmune disease affecting multiple organs, characterized by immune dysregulation.
Current blood-based gene expression studies offer insights but may miss tissue-specific factors driving SLE heterogeneity.
Significant unmet clinical needs persist in managing SLE and its diverse pathologies.

Purpose of the Study:

To investigate novel molecular patterns underlying distinct SLE pathologies using integrated multidimensional profiling.
To identify tissue-specific mechanisms contributing to SLE disease heterogeneity and progression.
To explore the potential of integrated data analysis for discovering new therapeutic targets in SLE.

Main Methods:

Integrated immune cell, protein, and transcriptome datasets from 87 SLE patients.
Correlated molecular data with disease activity and damage indices.
Utilized multidimensional analyses to identify independent protein signatures.

Main Results:

Identified three independent protein signatures linked to specific organ pathologies and immune perturbations in SLE.
Discovered a novel immune cell priming protein signature associated with renal involvement and predicting future organ damage.
This signature, found in serum proteomics, outperformed conventional assessments and had broad relevance, with signatures showing 94% combined prevalence.

Conclusions:

Revealed parallel immune mechanisms operating in SLE.
Provided a framework for identifying novel therapeutic targets for SLE.
Developed an interactive SLE Immune Atlas for public data exploration.