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Drug-Related Uveitis: A Real-World Study Based on the Food and Drug Administration Adverse Event Reporting System
Bing Yan1, Shi-Nan Wu1, Xiao-Dong Chen1
1Xiamen University affiliated Xiamen Eye Center; Fujian Provincial Key Laboratory of Ophthalmology and Visual Science; Fujian Engineering and Research Center of Eye Regenerative Medicine; Eye Institute of Xiamen University; School of Medicine, Xiamen University, Xiamen, Fujian, China.
Summary
This study identified 39 drugs linked to drug-related uveitis (DRU), with faricimab, pegcetacoplan, and rifabutin posing the highest risks. Early identification of DRU risks is crucial for prevention.
Area of Science:
- Pharmacovigilance
- Ophthalmology
- Drug Safety
Background:
- Drug-related uveitis (DRU) is a significant adverse drug event.
- Understanding the epidemiological characteristics and risk factors of DRU is crucial for patient safety.
- Real-world data analysis provides valuable insights into drug safety profiles.
Purpose of the Study:
- To assess the drug risk of drug-related uveitis (DRU) using real-world data.
- To identify specific drugs associated with DRU and quantify their risk.
- To track the epidemiological trends and characteristics of DRU.
Main Methods:
- Analysis of adverse drug event data from the FDA Adverse Event Reporting System (FAERS) database (2004-2024).
- Application of disproportionality analysis and Bayesian Confidence Propagation Neural Network (BCPNN) algorithm.
- Classification of DRU, risk assessment, and comparison of drug-induced onset times.
Main Results:
- 39 drugs identified with positive signals for DRU out of 269 reported.
- High-risk drugs include faricimab, pegcetacoplan, and rifabutin.
- Antibiotics showed the shortest onset time (20.55 days); females and the elderly were predominantly affected. DRU incidence shows an increasing trend over 20 years.
Conclusions:
- Preventing DRU is more effective than treatment.
- Identifying drug risks and onset times aids medication evaluation and DRU prevention.
- Real-world data analysis is vital for proactive drug safety monitoring.
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