Multi-Activity Nanozyme-Integrated Scaffolds: Harnessing Synergistic Enzyme-like Effects for Complete Treatment of
Zhengguang Wang1, Qian Wang2,3, Kaixi Liu4
1Department of Orthopedics, Peking University Third Hospital, 100191 Beijing, China.
ACS Nano
|February 24, 2026
Summary
A new nanozyme platform treats infected bone defects by killing bacteria and promoting bone growth. This 3D-printed titanium scaffold offers a dual approach for enhanced bone repair and infection control.
Area of Science:
- Biomaterials Science
- Nanotechnology
- Orthopedic Surgery
Background:
- Infected bone defects present significant clinical challenges due to infection, poor vascularization, and bone loss.
- Current implant materials inadequately address long-term infection control and tissue regeneration needs.
Purpose of the Study:
- To introduce a multifunctional nanozyme platform for treating infected bone defects.
- To leverage synergistic nanozyme activities and controlled ion release for bacterial death and tissue regeneration.
Main Methods:
- Fabrication of a 3D-printed titanium scaffold.
- Functionalization of the scaffold with an iron sulfide multiactivity nanozyme (ISMNzyme)-modified hydrogel.
- Evaluation of the platform's synergistic enzymatic activities (peroxidase-like, myeloperoxidase-like, GSH-Px-like) and controlled release of Fe2+ and polysulfides.
Main Results:
- The nanozyme platform demonstrated synergistic activities, inducing ferroptosis-like bacterial death.
- The platform concurrently promoted angiogenesis and osteogenesis.
- The dual mechanism effectively addressed infection and facilitated bone regeneration.
Conclusions:
- The multifunctional nanozyme platform shows promise for treating infected bone defects.
- This nanozyme-based strategy offers a novel approach for combined infection control and bone tissue engineering.
- The platform's integrated functionalities represent a significant advancement in orthopedic regenerative medicine.
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