Multi-Activity Nanozyme-Integrated Scaffolds: Harnessing Synergistic Enzyme-like Effects for Complete Treatment of
Zhengguang Wang1, Qian Wang2,3, Kaixi Liu4
1Department of Orthopedics, Peking University Third Hospital, 100191 Beijing, China.
Abstract:
Infected bone defects pose a major clinical challenge because they typically involve severe infection, poor vascularization, and bone loss. Existing implant materials lack integrated functionality for long-term infection control and tissue regeneration. Here, a multifunctional nanozyme platform consisting of a 3D-printed titanium scaffold functionalized with an iron sulfide multiactivity nanozyme (ISMNzyme)-modified hydrogel is introduced. The platform leverages synergistic peroxidase-like, myeloperoxidase-like, and glutathione peroxidase (GSH-Px)-like activities, alongside the controlled release of Fe2+ and polysulfides. This dual mechanism induces ferroptosis-like bacterial death while concurrently promoting angiogenesis and osteogenesis. The platform represents a promising nanozyme-based strategy for the treatment of infected bone defects.
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