Musculoskeletal Infection Reporting and Data System (MSKI-RADS): reviewed and explained

Angela He1, Flavio Duarte Silva1, Mina Guirguis1

  • 1Department of Radiology, UT Southwestern Medical Center, Dallas, TX, USA.

Insights Into Imaging
|February 24, 2026
PubMed

Insights

A new MRI guideline, the Musculoskeletal Infection Reporting and Data System (MSKI-RADS), standardizes the evaluation of musculoskeletal infections. This system improves reporting accuracy, patient management, and facilitates future research.

Area of Science:

  • Radiology
  • Musculoskeletal Imaging
  • Infectious Diseases

Background:

  • Current MRI terminology for musculoskeletal infections lacks specificity, leading to ambiguous diagnostic reports.
  • A standardized guideline is essential for consistent and accurate reporting of musculoskeletal infections via MRI.

Purpose of the Study:

  • To introduce and explain the Musculoskeletal Infection Reporting and Data System (MSKI-RADS), a validated MRI-based classification system.
  • To detail the technical considerations, severity scales, and management recommendations associated with MSKI-RADS for musculoskeletal infections.

Main Methods:

  • This review article details the MSKI-RADS classification system.
  • It includes a review of pertinent literature and provides examples of musculoskeletal infections across different severity classes.
  • Technical considerations for optimal MRI acquisition for musculoskeletal infections are outlined.

Main Results:

  • MSKI-RADS provides a standardized approach to classifying the severity and extent of musculoskeletal infections on MRI.
  • The system enhances radiology-pathology concordance and guides management recommendations.
  • It facilitates improved multidisciplinary communication and longitudinal data collection for research.

Conclusions:

  • MSKI-RADS is a validated MRI guideline for musculoskeletal infections in the extremities.
  • Adoption of MSKI-RADS can lead to standardized diagnostic reporting, improved patient outcomes, and streamlined treatment protocols.