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Updated: Feb 26, 2026
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Author Spotlight: Investigating the Pathophysiology of Eosinophilic Esophagitis
Published on: May 10, 2024
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Eosinophilic Ascites: An Underrecognized Entity in Peritoneal Disorders.
Rishi Chowdhary1, Zainab Awan2, Param Darpan Sheth3
1Department of Medicine, MetroHealth Medical Center, 2500 MetroHealth Drive, Cleveland, OH, 44109, USA. rxc822@case.edu.
Digestive Diseases and Sciences
|February 24, 2026
Summary
Eosinophilic ascites (EA) is a rare condition often misdiagnosed. Prompt corticosteroid treatment is effective, but more research is needed for diagnostics and relapses.
Area of Science:
- Gastroenterology and Immunology
Background:
- Eosinophilic ascites (EA) is a rare condition characterized by eosinophil-rich peritoneal fluid, often misdiagnosed.
- It is frequently associated with eosinophilic gastroenteritis (EGE) and presents in adults aged 30-50.
Purpose of the Study:
- This review consolidates current knowledge on eosinophilic ascites.
- It focuses on etiology, pathophysiology, diagnostic challenges, and treatment strategies, identifying knowledge gaps.
Main Methods:
- A narrative review of studies from 2000-2025 was conducted using PubMed, SpringerLink, and Web of Science.
- Included studies required histopathologically confirmed EA with ascitic eosinophilia >10%, imaging, and treatment outcomes.
Main Results:
- EA pathogenesis involves IL-5-driven eosinophilic infiltration of the gastrointestinal serosa.
- Diagnostic features include exudative ascites with eosinophilic predominance, peripheral eosinophilia, and bowel wall thickening on CT.
- Corticosteroids achieve remission in 80% of patients within two weeks.
Conclusions:
- Heightened clinical suspicion is crucial for diagnosing eosinophilic ascites.
- Future research should focus on non-invasive diagnostics, comparing biologics with steroids, and exploring genetic factors in refractory cases.
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