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Impact of Perforin 1 A91V germ line background in patients with aggressive B-NHL treated with R-CHOP

Onur Cetin1, Igor Kos1, Evi Regitz1

  • 1José Carreras Center for Immuno- and Gene Therapy and Department of Internal Medicine I, Saarland University Medical School, Homburg, Germany.

Blood Advances
|February 24, 2026
PubMed
Abstract

No abstract available in PubMed .

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Organisms are capable of detecting and fixing nucleotide mismatches that occur during DNA replication. This sophisticated process requires identifying the new strand and replacing the erroneous bases with correct nucleotides. Mismatch repair is coordinated by many proteins in both prokaryotes and eukaryotes.
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