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Quantum-Safe Digital Twin Authentication for ML-Driven Early Disease Detection in Healthcare Systems
IEEE Journal of Biomedical and Health Informatics
|February 24, 2026
Summary
This study introduces a secure digital twin framework for machine learning-based disease detection, enhancing patient privacy and real-time health monitoring. A quantum-resistant authentication method ensures data security against potential threats.
Area of Science:
- Healthcare technology
- Artificial intelligence in medicine
- Cybersecurity in healthcare
Background:
- Smart healthcare services like disease detection and patient monitoring face significant privacy and security challenges.
- Sensitive health data requires robust protection within the evolving digital healthcare ecosystem.
Purpose of the Study:
- To propose a secure digital twin-enabled machine learning (ML) framework for disease detection.
- To enhance patient privacy and enable secure real-time health data synchronization and risk identification.
Main Methods:
- Developed a digital twin framework integrating ML-based disease detection with a privacy-preserving environment.
- Implemented a lattice-based authentication scheme for quantum threat resistance.
- Conducted experiments to evaluate authentication and ML detection robustness, including white-box attack simulations.
Main Results:
- The proposed framework enables secure synchronization of real-time patient data to digital twins for health monitoring.
- Experimental results validate the robustness of the lattice-based authentication and ML disease detection.
- White-box attack experiments highlight the critical need for a secure data pipeline to prevent model collapse.
Conclusions:
- A secure digital twin framework with quantum-resistant authentication is effective for ML-based disease detection.
- Ensuring data pipeline security from collection to processing is vital for maintaining model integrity and patient data protection.

