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Shifting Patterns of Allergen Sensitization in 8,797 Children with Atopic Dermatitis during the COVID-19 Restriction
Xinmin Qiu1, Jiazhen Shi1, Hongqin Gu1
1Department of Clinical Laboratory, Hangzhou Third People's Hospital, Hangzhou, China.
Introduction:
This study aimed to characterize the allergen sensitization pattern among children with atopic dermatitis (AD) in Hangzhou, China, and to investigate the impact of COVID-19 restriction measures on these patterns.
Methods:
In this retrospective study of 8,797 children with AD, we analyzed specific immunoglobulin E (sIgE) results. We assessed sensitization prevalence and intensity, and used multivariable logistic regression to evaluate independent associations, including restriction phase (pre-, during-, post-), while adjusting for age, gender, and season.
Results:
The overall sensitization prevalence was 73.2%. House dust mite was the dominant sensitizer (45.6%), with the highest median sIgE level (19.05 IU/mL) and proportion of high-level sensitization (73.65%). Restriction measures were independently associated with a sharp decline in risk for most inhalant allergens during the restriction phase (OR = 0.40, 95% CI: 0.36-0.45), followed by significant post-restriction recovery (OR = 0.81, 95% CI: 0.73-0.90). In contrast, house dust mite sensitization risk increased post-restriction (OR = 1.33, 95% CI: 1.21-1.47). Food allergen sensitization showed a delayed, pronounced decline post-restriction (OR = 0.49, 95% CI: 0.44-0.54). Male gender and increasing age were confirmed as independent risk factors. Furthermore, distinct seasonal fluctuations were observed, with a higher risk of sensitization to various inhalant allergens during autumn and winter.
Conclusion:
The allergen sensitization profile in Hangzhou is distinct and heavily dominated by house dust mite. COVID-19 restriction measures were independently associated with divergent, allergen-specific shifts, highlighting the profound influence of environmental and behavioral factors. These findings advocate for dynamic, region-specific management and inform public health planning for allergic diseases.
