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Updated: Feb 26, 2026

An In Vitro Bladder Model of Catheter-Associated Urinary Tract Infection
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Host Pathogen Interactions during Catheter-Associated Urinary Tract Infections.

Kurt N Kohler1, Alyssa Ann La Bella1, Ana Lidia Flores-Mireles1

  • 1Department of Biological Sciences, University of Notre Dame, Notre Dame, Indiana 46556, United States.

ACS Infectious Diseases
|February 24, 2026
PubMed
Summary
This summary is machine-generated.

Catheter-associated urinary tract infections (CAUTIs) are challenging due to resistant pathogens. Fibrinogen deposits create a niche for pathogens, impacting host immunity and leading to persistent infections.

Keywords:
catheter-associatedpathogenurinary tract infection

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Area of Science:

  • Microbiology
  • Immunology
  • Infectious Diseases

Background:

  • Catheter-associated urinary tract infections (CAUTIs) are a major healthcare challenge.
  • CAUTIs involve multidrug-resistant and polymicrobial pathogens.
  • Urinary catheterization induces inflammation and fibrinogen deposition.

Purpose of the Study:

  • To examine pathogen strategies in catheterized bladders.
  • To understand the host immune response to CAUTI.
  • To explore novel therapeutic strategies for CAUTI prevention.

Main Methods:

  • Review of host-pathogen interactions in CAUTI.
  • Analysis of fibrinogen's role in biofilm formation.
  • Examination of immune modulation by fibrinogen deposits.

Main Results:

  • Fibrinogen deposition creates a niche for uropathogen persistence.
  • Uropathogens utilize fibrinogen for biofilm formation.
  • Fibrinogen influences host immune responses.

Conclusions:

  • Understanding fibrinogen-pathogen interactions is key to combating CAUTI.
  • Targeting fibrinogen-binding adhesins offers potential antimicrobial-sparing therapies.
  • Developing novel prevention strategies is crucial for reducing CAUTI prevalence.