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Updated: Feb 26, 2026
07:57
An In Vitro Bladder Model of Catheter-Associated Urinary Tract Infection
Published on: June 24, 2025
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Host Pathogen Interactions during Catheter-Associated Urinary Tract Infections.
Kurt N Kohler1, Alyssa Ann La Bella1, Ana Lidia Flores-Mireles1
1Department of Biological Sciences, University of Notre Dame, Notre Dame, Indiana 46556, United States.
ACS Infectious Diseases
|February 24, 2026
Summary
Catheter-associated urinary tract infections (CAUTIs) are challenging due to resistant pathogens. Fibrinogen deposits create a niche for pathogens, impacting host immunity and leading to persistent infections.
Area of Science:
- Microbiology
- Immunology
- Infectious Diseases
Background:
- Catheter-associated urinary tract infections (CAUTIs) are a major healthcare challenge.
- CAUTIs involve multidrug-resistant and polymicrobial pathogens.
- Urinary catheterization induces inflammation and fibrinogen deposition.
Purpose of the Study:
- To examine pathogen strategies in catheterized bladders.
- To understand the host immune response to CAUTI.
- To explore novel therapeutic strategies for CAUTI prevention.
Main Methods:
- Review of host-pathogen interactions in CAUTI.
- Analysis of fibrinogen's role in biofilm formation.
- Examination of immune modulation by fibrinogen deposits.
Main Results:
- Fibrinogen deposition creates a niche for uropathogen persistence.
- Uropathogens utilize fibrinogen for biofilm formation.
- Fibrinogen influences host immune responses.
Conclusions:
- Understanding fibrinogen-pathogen interactions is key to combating CAUTI.
- Targeting fibrinogen-binding adhesins offers potential antimicrobial-sparing therapies.
- Developing novel prevention strategies is crucial for reducing CAUTI prevalence.
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