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Related Concept Videos

In Vitro Fertilization01:24

In Vitro Fertilization

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In vitro fertilization (IVF) is a form of assisted reproductive technology where an egg is fertilized with sperm in a controlled laboratory environment before transferring the resulting embryo into the uterus. This process is designed to help individuals and couples experiencing difficulties conceiving.
The IVF process begins with ovarian stimulation, during which reproductive endocrinologists prescribe hormonal medications to stimulate the ovaries to produce multiple eggs instead of the single...
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Nondisjunction is the failure of homologous chromosomes or sister chromatids to separate correctly and move to the opposite poles of the cells. This produces daughter cells with abnormal chromosome numbers.  Nondisjunction is common during anaphase I or anaphase II of meiosis.  Mutations in synaptonemal complex proteins that attach homologous chromosomes increase the chances of nondisjunction in anaphase I of meiosis I. In contrast, mutations in topoisomerases and condensins that hold...
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Preimplantation genetic testing for aneuploidy mosaicism reporting lacks clinical predictive value for live birth in a multisite, double-blinded study with independent validation.

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Related Experiment Video

Updated: Feb 26, 2026

Semiconductor Sequencing for Preimplantation Genetic Testing for Aneuploidy
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Using Preimplantation Genetic Testing for Aneuploidy (PGT-A) Validation Data to Inform Clinical In Vitro

Andria Besser1, Mina Popovic2, Eric Forman3

  • 1NYU Langone Fertility Center, NYU Langone Health, New York, New York.

Seminars in Reproductive Medicine
|February 24, 2026
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Summary
This summary is machine-generated.

Preimplantation genetic testing for aneuploidy (PGT-A) is vital for in vitro fertilization (IVF) but requires validated methods. Understanding PGT-A test performance is crucial for accurate embryo selection and improved IVF success rates.

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Area of Science:

  • Reproductive Medicine
  • Genetics
  • In Vitro Fertilization

Background:

  • Preimplantation genetic testing for aneuploidy (PGT-A) is a common IVF procedure.
  • PGT-A test performance and interpretation vary significantly across laboratories and platforms.
  • Clinical utility of PGT-A depends heavily on validated test accuracy.

Purpose of the Study:

  • Define PGT-A goals and evaluate validation methods.
  • Explore how validation data influences clinical decisions.
  • Address challenges with mosaicism and segmental aneuploidy PGT-A.

Main Methods:

  • Review of PGT-A methodologies and validation strategies.
  • Analysis of clinical impact of PGT-A results.
  • Focus on newer PGT-A diagnostic categories.

Main Results:

  • PGT-A effectiveness is tied to specific laboratory performance and interpretation.
  • Limited validation exists for mosaicism and segmental aneuploidy PGT-A.
  • Unvalidated PGT-A results can negatively affect IVF outcomes.

Conclusions:

  • Clinicians need transparent, assay-specific PGT-A validation data.
  • Evidence-based counseling is essential for embryo transfer decisions.
  • Responsible PGT-A use can optimize IVF success and embryo disposition.