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Related Concept Videos

Sensory Functions of the Skin01:16

Sensory Functions of the Skin

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The skin is the largest organ of the human body and plays a crucial role in our sensory perception. It contains a vast network of sensory receptors that contribute to the skin's protective function by perceiving physical, biological, and environmental cues and generating relevant responses.
There are two main categories of receptors on the skin: capsulated and non-capsulated. The non-capsulated ones are mainly the pain receptors. The capsulated ones can be further categorized based on the...
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Isolation of Cortical Microglia with Preserved Immunophenotype and Functionality From Murine Neonates
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Microglia Modulate Information Processing in the Mouse Barrel Cortex.

Bálint Király1,2, Eszter Császár3, Diána Balázsfi1,3

  • 1MTA-HUN-REN KOKI Lendület "Momentum" Laboratory of Systems Neuroscience, HUN-REN Institute of Experimental Medicine, Budapest H-1083, Hungary.

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
|February 24, 2026
PubMed
Summary
This summary is machine-generated.

Microglia regulate brain networks by modulating interneuron activity. Their absence or P2Y12R receptor dysfunction increases interneuron firing and cortical hypersynchrony, impacting sensory processing.

Keywords:
P2Y12Rfunctional connectivityinterneuronmicrogliasensory processing

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Area of Science:

  • Neuroscience
  • Immunology
  • Cell Biology

Background:

  • Microglia are key immune cells in the central nervous system, essential for brain homeostasis.
  • Their precise role in regulating neuronal networks and local microcircuits is not fully understood.
  • Understanding microglia-neuron interactions is crucial for deciphering sensory processing mechanisms.

Purpose of the Study:

  • To investigate the role of microglia in modulating neuronal network activity and functional connectivity.
  • To determine the impact of microglia depletion and P2Y12R receptor dysfunction on neural circuits.
  • To elucidate how microglia influence sensory processing at the single-cell and network levels.

Main Methods:

  • Utilized microglia-depleted mouse models and P2Y12R knockout (KO) mice.
  • Recorded neuronal activity at the single-cell level in the barrel cortex.
  • Assessed brain-wide functional connectivity using electrophysiological recordings during sensory stimulation.

Main Results:

  • Absence of microglia or P2Y12R increased baseline interneuron firing rates.
  • Microglia dysfunction led to cortical hypersynchrony, evidenced by increased delta oscillations.
  • Thalamocortical connectivity was reduced in microglia-depleted and P2Y12R KO mice during sensory processing.

Conclusions:

  • Microglia, particularly through the P2Y12R receptor, are critical regulators of neuronal network activity and sensory processing.
  • Microglial dysfunction can lead to interneuron hyperexcitability and cortical hypersynchrony.
  • These findings highlight the significant impact of neuroglial interactions on brain function in health and disease.