Related Experiment Video
Updated: Feb 26, 2026

Establishment of a Mouse Severe Acute Pancreatitis Model using Retrograde Injection of Sodium Taurocholate into the Biliopancreatic Duct
Published on: April 1, 2022
Therapeutic hopes for CFTR-related recurrent pancreatitis: a case-series
Sophie Gohy1, Anaïs Le2, Isabelle Sermet-Gaudelus2
1Pneumology department, Cliniques universitaires Saint-Luc, Brussels, Belgium; Cystic fibrosis reference center, Cliniques universitaires Saint-Luc, Brussels, Belgium; European Reference Network-Respiratory Diseases (ERN-LUNG); Pole of Pneumology, ENT and Dermatology (LUNS), Université catholique de Louvain (UCLouvain), Brussels, Belgium.
Abstract:
The presence of CFTR variants increases the risk of pancreatitis in pancreatic sufficient people with cystic fibrosis (pwCF) or with CFTR-related disorder (pwCFTR-RD). Modulators have been showed to decrease pancreatitis episodes in pwCF presenting recurrent pancreatitis. Whether CFTR modulators are efficient to prevent recurrent episodes of pancreatitis in pwCFTR-RD is not known. We collected clinical, biological, imaging and CFTR functional data in 4 patients with recurrent pancreatitis and CFTR-RD, treated with CFTR modulators and assessed the efficacy of the treatment. With a follow-up of minimum 9 months, we found that ETI and ivacaftor reduced or even resolved the number of acute pancreatitis episodes.
More Related Videos
07:04Forskolin-induced Swelling in Intestinal Organoids: An In Vitro Assay for Assessing Drug Response in Cystic Fibrosis Patients
Published on: February 11, 2017
05:56Implementation of Non-invasive Point of Care Transient Elastography for Evaluation of Liver Disease in Pediatric Populations with Cystic Fibrosis
Published on: August 29, 2025
Related Concept Videos
Chronic Pancreatitis II: Collaborative Care
Assessment:
Cystic Fibrosis: Management
Sinus disease and chronic...
Chronic Pancreatitis I: Introduction
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
Acute Pancreatitis II: Clinical Manifestations and Management
Cystic Fibrosis: Pathogenesis
CF is primarily caused by a genetic mutation in a chromosome 7 gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. The most common gene mutation leading to CF is the ΔF508 mutation,...
Acute Pancreatitis I: Introduction
Acute pancreatitis is characterized by rapid inflammation of the pancreas, often caused by factors like gallstone blockage or excessive alcohol consumption. Chronic pancreatitis, on the other hand, is a slow, progressive inflammation that may result from long-term alcohol abuse, obstructions in the pancreatic duct, or genetic factors.
The causes of acute pancreatitis include: