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A large-scale optogenetic neurophysiology platform for improving accessibility in non-human primate behavioral
Devon J Griggs1,2, Noah Stanis2,3, Julien Bloch2,3
1University of Washington Department of Electrical and Computer Engineering, Seattle, USA.
Nature Communications
|February 24, 2026
Summary
We developed a new platform integrating optogenetics and electrophysiology for non-human primate (NHP) studies. This tool enables simultaneous neural recording and behavioral modulation, advancing research in neurological disorders.
Area of Science:
- Neuroscience
- Biotechnology
Background:
- Optogenetics is a powerful tool, but its application in non-human primate (NHP) electrophysiology faces technical hurdles.
- Challenges include limitations in electrode arrays, viral vector delivery, cortical illumination hardware, and multi-modal experimental designs.
Purpose of the Study:
- To introduce a novel, accessible platform for integrating optogenetics and electrophysiology in NHPs.
- To enable simultaneous behavioral and neural modulation with neurophysiological recording.
Main Methods:
- Developed an integrated platform for optogenetics and electrophysiology.
- Utilized the platform in two rhesus macaques for behavioral disruption and neural recording.
Main Results:
- Demonstrated optogenetic disruption of reaches in NHPs.
- Simultaneously monitored electrocorticography activity during stimulation-induced behavioral changes.
- Showcased long-term stability and functionality of the platform over months.
Conclusions:
- The developed platform addresses key technical challenges in NHP optogenetics and electrophysiology.
- Facilitates large-scale, long-term multi-modal studies crucial for neurological and neuropsychiatric disorder research.
